阿司匹林联合地奥司明对大隐静脉曲张术后的疗效及对凝血功能血清serpine1 KLF2的影响

doi:10.3969/j.issn.1006-6233.2019.08.007

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Abstract Objective: To study the curative efficacy of aspirin combined with diosmin in treatment of postoperative varicose great saphenous vein and effects on coagulation function, serum plasminogen activator inhibitor(serpine1) and Kruppel like transcription factor 2(KLF2) levels. Methods: 95 patients of postoperative varicose great saphenous vein who received therapy from January 2016 to May 2018 in our hospital were as theis research, and they were divided into the 50 cases of the observation group and 45 cases of the control group by the simple random number table, they were given routine preventive treatment after operation on the basis of, the control group was given aspirin treatment, and the observation group was combined with Diosmin treatment on the basis of the control group, thye were given drugs continuously for 2 weeks. The coagulation function, serpine1, KLF2, leg symptoms, incidence of deep vein thrombosis in lower extremities and adverse reactions were compared between the two groups. Results: The activation time of partial thromboplastin (APTT), prothrombin time (PT) and thrombin time (TT) in the observation group were significantly longer than those in the control group at after treatment 3 and 7 days(P<0.05); the serum serpine1 in the observation group was significantly lower than those in the control group, and KLF2 was significantly higher than those in the control group at after treatment 3 and 7 days(P<0.05); after treatment, the weight and visual analogue scale (VAS) scores in the observation group were significantly lower than those in the control group(P<0.05); the incidence of deep vein thrombosis in lower extremities in the observation group was significantly lower than those in the control group(P<0.05); there was no significant difference in adverse reactions between the two groups during treatment(P>0.05). Conclusion: Aspirin combined with diosmin is well for postoperative varicose great saphenous vein, which can effectively regulate the serum serpine1 and KLF2 levels, improve the coagulation function, prevent the formation of deep vein thrombosis in lower extremities, and has high safety, it's worthy of clinical application and promotion.

Key words： Varicose great saphenous vein Aspirin Diosmin Coagulation function Deep vein thrombosis in lower extremities

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	SHI Wanqing
	CHEN Keli
	SONG Qinghong

Cite this article:

SHI Wanqing,CHEN Keli,SONG Qinghong. Curative Efficacy of Aspirin Combined with Diosmin in Treatment of Postoperative Varicose Great Saphenous Vein and Influence on Coagulation Function Serum Serpine1 and KLF2 Levels[J]. HeBei Med, 2019, 25(8): 1257-1260.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.08.007 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I8/1257

[1] Hwang JH, Park SW, Chang IS, et al. Endovenous thermal ablation of recurrent varicose veins due to residual great saphenous venous insufficiency after saphenous venous surgery: a comparative study[J]. Dermatol Surg, 2018, 44(10): 1287~1294.
[2] Guo T, Song H, Zhao Z, et al. Overexpression of annexin A2 receptor inhibits neovascularization via the promotion of kruppel-like transcription factor 2[J]. Cell Physiol Biochem, 2018, 46(4): 1617~1627.
[3] Bawa H, Weick JW, Dirschl DR, et al. Trends in deep vein thrombosis prophylaxis and deep vein thrombosis rates after total hip and knee arthroplasty[J].Am Acad Orthop Surg, 2018, 26(19): 698~705.
[4] 丁忠仁.抗血小板药:现状、挑战及趋势[J].中山大学学报(医学版),2018,39(4):481~492.
[5] 何文.地奥司明对围术期骨折患者深静脉血栓形成和凝血功能的影响分析[J].海峡药学,2016,28(08):144~146.
[7] Boisnic S, Branchet MC, Gouhier-Kodas C, et al. Anti-inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model[J]. J Cosmet Dermatol, 2018, 17(5): 848~854.
[8] Kuznetsov MR, Sapelkin SV, Boldin BV, et al. Recanalization of lower-limb deep veins as an index of efficacy of treatment for acute venous thrombosis[J]. Angiol Sosud Khir, 2016, 22(3): 82~88.
[9] Zudin AM, Zasorina MA, Vikhert TA, et al. Ultrasound assessment of alterations in venous haemodynamics in patients with post-thrombotic disease permanently taking phlebotonics[J]. Angiol Sosud Khir, 2014, 20(2): 52~57.
[9] Szotysek K, Janus P, Zajc G, et al. RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation[J]. BMC Genomics, 2018, 19(1): 813.
[10] Wang ZL, Wang YD, Wang K, et al. KFL2 participates in the development of ulcerative colitis through inhibiting inflammation via regulating cytokines[J]. Eur Rev Med Pharmacol Sci, 2018, 22(15): 4941~4948.
[11] Li J, Dai AG, Huang CY, et al. Effect of Kruppel like zinc finger transcription factor 2 on γ-glutamylcysteine synthetase in bronchial epithelial cells of chronic obstructive pulmonary disease[J].Chinese Medical Journal, 2017, 97(2): 112~118.