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The Efficacy of Aspirin in the Treatment of Primary Hypertension with CHD and its Effect on Plasma Viscosity and Platelet Aggregation Rate |
CUI Linlin, GAO Guojie, HU Taohong |
The General Hospital of Rocket Army, Beijing 100088, China |
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Abstract Objective: To observe the curative efficiency of aspirin on primary hypertension combined with coronary heart disease(CHD) and its influence on plasma viscosity and platelet aggregation rate. Methods: A total of 107 cases of primary hypertension patients with coronary heart disease were randomly divided into two groups by the random number table method: the study group (56 cases) and the control group (51 cases). The control group were given Telmisartan (40mg/d), Isosorbide Dinitrate tablets (30mg once, 3 times per day), while the study group were given aspirin (100mg/d) on the basis of the control group. Compare the blood pressure, blood lipid levels, left ventricular ejection fraction (LVEF), plasma viscosity and platelet aggregation rate changes of the two groups before and after 6 months' treatment. Results: After 6 months' treatment, the level of blood pressure, TC, TG, plasma viscosity and platelet aggregation rate of both groups were all declined on different degree, while the level of plasma viscosity and platelet aggregation rate of the study group were more significant lower than that of the control group (P<0.05). In addition, the LVEF of both groups were all increased significantly (P<0.01), and the LVEF level of the study group were significantly higher than the control group (P<0.05); the total effective rate of the study group were significantly higher than the control group (90.9% vs 76.5%, P<0.05). Conclusion: The therapy of aspirin can improve the blood viscosity and LVEF level for primary hypertension patients with CHD, and improve the curative efficiency as well.
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