不同剂量右美托咪定复合地塞米松对肺缺血再灌注大鼠模型炎症因子白三烯及组胺水平的影响

doi:10.3969/j.issn.1006-6233.2018.01.039

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Abstract Objective: To investigate the effects of different doses of dexmedetomidine combined with dexamethasone on the levels of inflammatory cytokines and histamine in rats with lung ischemia-reperfusion injury. Methods: 50 SD rats were randomly divided into four groups: sham operation group, model group, dexmedetomidine high dose group, dexmedetomidine group, dexmedetomidine low dose group, each group of 10 rats. According to the literatures, the model of lung ischemia-reperfusion injury was established. After the modeling, dexmedetomidine low, middle and high dose group rats were given dexmedetomidine 1, 5, 10μg/kg loading dose, then in 1, 5, 10μg·kg^-1·h^-1 were treated with continuous infusion of 1H; dexamethasone 0.2 mg/kg, intratracheal instillation, and then to 3 mg/kg intravenous injection; intravenous infusion of saline model group and sham operation group were given the same amount of medication for 4 weeks. The tumor necrosis factor α (TNF-α), interleukin -1 β (IL-1β), histamine (HIS) and leukotriene B4 (LTB4) levels were observed and compared in each group. Results: Compared with model group, dexmedetomidine group and high dose of dexmedetomidine in dose of TNF- α, IL-1β, HIS and LTB4 levels were decreased, the difference was statistically significant (P<0.05), TNF- α, IL-1β, HIS and LTB4 levels in dexmedetomidine high dose group and dexmedetomidine dose group, the difference was not statistically significant (P>0.05). Conclusion: Dexmedetomidine combined with dexamethasone can control lung ischemia reperfusion rat model of inflammation, reduce the leukotriene and histamine levels, but increase the dose limited protective effect, showed no significant protective effect.

Key words： Dexmedetomidine Dexamethasone Lung ischemia reperfusion Inflammatory factor Leukotrienes Histamine

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LI Guanjun. Effects of Different Doses of Dexmedetomidine combined with Dexamethasone on the Levels of Inflammatory Cytokines and Histamine in rats with Lung Ischemia-reperfusion Injury[J]. HeBei Med, 2018, 24(1): 145-152.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.01.039 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I1/145

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