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| The Expression of HGF and its Receptor c-met in Human Esophageal Carcinomaand the Relationship to Lymphangiogenesis and Lymphatic Metastasis of EC |
| ZHAO Yang, LIU Shasha, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To determin the expression of HGF and its receptor c-met in human esophageal carcinoma and to investigate the relationship between HGF and its receptor with lymphangiogenesis and lymphatic metastasis of EC. Method: Immunohistochemical staining was used to examine expression of HGF and c-met in 30 cases of NM and 70 cases of EC tissues.The microlymphatic density (LMVD) in esophageal carcinoma was calculated by D2-40 as the specific marker of lymphatic endothelium. Results: Expression of HGF and c-met in EC showed significantly higher than that in NM, and they were positively correlated with lymphangiogenesis and lymphatic metastasis of EC. Conclusion: The overexpression of HGF and c-met may play an important role in lymphangiogenesis and lymphatic metastasis of EC.
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2018, Vol. 24 
