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| Effects of Simvastatin Combined CoenzymeQ10 on Ventricular Remodeling and Cardiac Function in Rats with CHF |
| YU Hairong, et al |
| Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the effects of simvastatin combined coenzymeQ10 on ventricular remodeling and cardiac function in rats with chronic heart failure (CHF). Methods: 40 SD rats were randomly divided into five groups:sham-operated group,coenzymeQ10 group,simvastatin group,simvastatin combined coenzymeQ10 group and model group.Coarctation of abdominal aorta (CCA) except for the shame-operated group. Testing hemodynamic of left ventricular end-diastolic diameter press (LVEDP),left ventricular pressure rise and fall (±dp/dtmax),left ventricular mass/body mass (LVMI);HE and Masson’s trichrome staining for morphology. Results: Compared with model group, hemodynamic analysis revealed that left ventricular end-diastolic pressure (LVEDP) were significantly lower in simvastatin group, coenzymeQ10, simvastatin combined coenzymeQ10 group(P<0.01), left ventricular pressure rise and fall increased remarkable(P<0.01);In addition, left ventricular mass/body mass (LVMI) and collagen volume fraction(CVF%) was decreased sharply(P<0.01).CoenzymeQ10 group,simvastatin combined coenzymeQ10 groups improved CHF remarkable than rest groups (P< 0.05).Conclusion: All of these results verify that treatment with simvastatin combined coenzymeQ10 has more obvious effects on improving heart function of rats with cardiac remodeling and inhibit ventricular remodeling.
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2016, Vol. 22 
