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| Influence of Ambroxol joint Reynolds Nasal Spray on Serum and Middle Ear Effusion on HA,sIL-2R, Fn and Inflammatory Media in the Treatment Secretory Otitis Media |
| YAN Bin, WU Wenwen, LIU Bo, et al |
| Xianyang Central Hospital, Shaanxi Xianyang 712000, China |
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Abstract Objective: To research Influence of ambroxol joint Reynolds nasal spray on serum and middle ear effusion on hyaluronic acid (HA), Soluble interleukin-2 receptor (sIL-2 R), fibronectin (Fn) and inflammatory media in the treatment secretory otitis media. Methods: 86 cases of secretory otitis media was from May 2013 to November 2016, according to lottery method was divided into control group and research group, 43 cases in each group. The control group was treated with the basic treatment, and the research group was treated with ambroxol joint Reynolds nasal spray based on control group. Clinical curative effect, serum HA and middle ear effusion, sIL-2 R, Fn, interleukin 1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), and adverse reactions occur between two group were observed and compared. Results: Total effective rate of the research group was significantly higher than the control group, and the difference was statistically significant (P<0.05). After treatment, two groups of serum and middle ear effusion HA, sIL-2 R, IL-1β, IL-8, TNF-α, PCT was significantly lower than befroe treatment, research group was significantly lower than the control group, Fn of two group was significantly higher than control group, the control group was significantly higher than the control group, the differences were statistically significant (P<0.05). The total adverse effects rate of two group was not statistically significant (P>0.05). Conclusion: Effect is sure of ambroxol joint Reynolds nasal spray in the treatment secretory otitis media,wich can reduce serum and middle ear effusion HA, sIL-2R and inflammatory mediators, improve the level of Fn.
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[1] Edmunds AL. Otiprio: an FDA-approved ciprofloxacin suspension gel for pediatric otitis media with effusion[J]. P T, 2017,42(5):307~311.
[2] Kim SH, Jeon EJ, Hong SM, et al. Bacterial species and antibiotic sensitivity in korean patients diagnosed with acute otitis mediaand otitis media with effusion[J].Korean Med Sci,2017,32(4):672~678.
[3] Neff BA, Voss SG, Carlson ML, et al. Treatment of eosinophilic otitis media with pegylated interferon-α 2a and 2b[J]. Laryngoscope,2017,127(5):1208~1216.
[4] Wilhelm T, Stelzer T, Hagen R. Sensorineural hearing loss after otitis media with effusion and subacute mastoiditis after viral infections of the upper respiratory tract: A comparative study of conservative and surgical treatment[J]. Ear Nose Throat J,2016 ,95(9):E18~E27.
[5] CalimoF, Yildirim YS, Dogan R, et al. Evaluation of the protective effect of botulinum toxin type A injection on otitis media with effusion<sup/>[J]. Acta Otolaryngol,2017,137(9):917~922.
[6] Cai T, McPherson B. Hearing loss in children with otitis media with effusion: a systematic review[J]. Int Audiol, 2017,56(2):65~76.
[7] Demant MN, Jensen RG, Jakobsen JC, et al. The effects of ventilation tubes versus no ventilation tubes for recurrent acute otitis media or chronic otitis media with effusion in 9 to 36 month old Greenlandic children, the SIUTIT trial: study protocol for a randomized controlled trial[J]. Trials, 2017 ,18(1):30.
[8] Krueger A, Val S, Perez-Losada M, et al. Relationship of the middle ear effusion microbiome to secretory mucin production in pediatric patients with chronic otitis media[J]. Pediatr Infect Dis,2017,36(7):635~640.
[9] Harabuchi Y, Kishibe K, Tateyama K,et al. Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan[J]. Mod Rheumatol, 2017,27(1):87~94.
[10] Val S, Jeong S, Poley M,et al. Purification and characterization of microRNAs within middle ear fluid exosomes: implication in otitismedia pathophysiology[J]. Pediatr Res,2017,81(6):911~918.
[11] Amer HS, El-Anwar MW, Elfeky AE. The Efficacy of adjuvant intratympanic steroid treatment for otitis media with effusion in children[J]. Int Arch Otorhinolaryngol, 2016 ,20(3):244~247. |
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2018, Vol. 24 
