AbstractObjective: To observe the expression of CK20, HIF-1α and PKM2 in colorectal cancer tissues. Methods: 73 cases of colorectal cancer tissue specimens in our hospital from December 2015 to December 2016 were selected as the research object (colorectal cancer group), and choose another 30 cases of normal colorectal tissue specimens as the control group. The expression of CK20, HIF-1α and PKM2 were detected by the immunohistochemical method. Results: In the colorectal cancer group, there was no significant differences of the expression rate of CK20, HIF-1α and PKM2 under different age, sex and differentiation degree(P>0.05), but the expression rate of different lymph node metastasis and Dukes stages of CK20, HIF-1α and PKM2 was statistically significant (P<0.05); In the colorectal cancer group, CK20 was positively related with HIF-1α (r=0.751, P<0.01); and PKM2 was positively related with HIF-1α, too (r=0.926, P<0.01)3. The expression of CK20, HIF-1α and PKM2 of the colorectal cancer group were significantly higher than those of the control group (P<0.05). Conclusion: The expression of CK20 and HIF-1α of the colorectal cancer tissue specimens are significantly higher than that of the colorectal normal tissue specimens, which showed certain prediction value on tumor value-added and metastasis for colorectal cancer patients.
[1] 汪建平.中国结直肠癌治疗现状-进步与局限并存[J]中华胃肠外科杂志,2012,15:989~992. [2] Wang J, Liu L, Qiu H, et al. Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells[J].PLoS One,2013,8(5):e63872. [3] Edwards BK, Brown ML, Wingo PA, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment[J].Natl Cancer Inst,2005,97(19):1407~1427. [4] 顾晋.重视结直肠癌的术前分期规范结直肠癌的综合治疗[J].中华外科杂志,2012,50(3):193~195. [5] Ping-Ping Bao, Ying Zheng, Chun-Xiao Wu, et al.Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects[J].BMC Cancer,2016,16: 284. [6] 周明利.HlF-1α与EMT在肿瘤中的作用及意义研究进展[J].中国普通外科杂志,2012,21(9):1132~1136. [7] 林萍,邓涛,叶彦,等.人结直肠癌组织中mTOR、HIF-1α、PKM2的表达及临床意义[J].疑难病杂志,2015,14(4):380~383,441. [8] 王茜,时延龙,毕经旺.p-mTOR与HIF-1α在结直肠癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2015,22(6):779~784. [9] Nemazanyy I, Espeillac C, Pende M, et al.Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression[J].Biochem Soc Trans,2013,41(4):917~922. [10] 时蒙昆,时雨,王群.肿瘤中m2型丙酮酸激酶的表达、功能及调节[J].复旦学报(医学版),2017,44(2):217~223. [11] 孙倩.m2型丙酮酸激酶(PKM2)在肿瘤代谢和发生中的作用[J].基础医学与临床,2012,32(5):462~467.
2018, Vol. 24 
