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| Effects of Alprostadil Combined with Electromyographic Biofeedback Therapy on Limb Function and Excitability of Spinal Motor Neurons in Patients with Spastic Hemiplegia after Stroke |
| SUN Junhui, QI Yanying, FENG Xiufang, et al |
| Tangshan Workers Hospital, Hebei Tangshan 063000, China |
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Abstract Objective: To analyze the effects of alprostadil combined with electromyographic biofeedback therapy on limb function and excitability of spinal motor neurons in patients with spastic hemiplegia after stroke. Methods: 91 patients with post-stroke spastic hemiplegia admitted to our hospital from January 2016 to October 2017 were divided into 43 cases of control group and 48 cases of observation group according to random number table method. The control group was treated with emg biofeedback therapy, and the observation group was treated with alprostadil based on the control group. Then modified Ashworth scale efficacy, limb function, Hmax, Mmax and H/Mmax, neurologic deficit (NDS) and daily life activity (ADL) scores in both groups were compared. Results: Effective rate in the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, Fugl-Meyer function for upper and lower limbs in both group were no statistically significant difference (P>0.05). After treatment, the fugl-meyer functional scale of upper and lower limbs in both group were increased, and the observation group was higher than the control group, with statistically significant difference (P<0.05). Before treatment, Hmax, Mmax and H/Mmax in both group were no difference (P>0.05). After treatment, Hmax, Mmax and H/Mmax in both groups were decreased, and the observation group was lower than the control group (P<0.05). NDS score in both group was rised, ADL score was falled,and the observation group were more significant change (P<0.05). Conclusion: Alprostadil combined with emg biofeedback therapy has a positive effect on the improvement of limb function in patients with post-stroke paralysis. It can reduce muscle tension and reduce spasm by regulating excitability of spinal motor neurons.
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2018, Vol. 24 
