生长抑素联合地塞米松对腹部术后早期炎性肠梗阻的疗效及对胃肠功能和血清LPS IL-6 hs-CRP的影响

doi:10.3969/j.issn.1006-6233.2018.12.014

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Abstract Objective: To investigate the clinical efficacy of somatostatin combined with dexamethasone on early postoperative inflammatory ileus after abdominal operation and its influence on patients' gastrointestinal function and their serum lipopolysaccharide (LPS), interleukin -6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) levels. Methods: The subjects of this study were selected from 138 cases of patients with early postoperative inflammatory ileus after abdominal operation admitted in our hospital from May 2015 to June 2017. The patients were according to simple random number table method were divided into observation group and control group, each with 69 cases. Besides conventional treatment given to both groups, dexamethasone was adopted to the control group in addition, and combination of somatostatin and dexamethasone was given to the observation group additionally. The clinical efficacy, the recovery status of gastrointestinal function, and changes of serum LPS, IL-6, hs-CRP levels before and after treatment were compared between the two groups. Results: The overall effective rate of the observation group was 91.30% (63/69), much higher than 75.36% (52/69) of the control group (P<0.05). The time for resuming of peristaltic sound, postoperative exhausting, release of abdominal pain and distention, extinction of nausea and vomitting that the observation group took was significantly shorter than the time the control took (P<0.01). After treatment, both groups saw great decrease in serum LPS, IL-6 and hs0CRP levels as compared with those before treatment (P<0.01), and observation group had remarkably lower levels of above indicators than the control group did at the identical time points after treatment (P<0.01). Conclusion: Application of somatostatin combined with dexamethasone in treating early postoperative inflammatory ileus after abdominal operation is effective in promoting the recovery of gastrointestinal function and mitigating inflammatory reactions.

Key words： Somatostatin Dexamethasone Early postoperative inflammatory ileus Gastrointestinal function

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	ZHANG Ruipeng
	DAI Yi
	WANG Hui

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ZHANG Ruipeng,DAI Yi,WANG Hui. Somatostatin Combined with Dexamethasone on Early PostoperativeInflammatory Ileus after Abdominal Operation and its Influence on the Gastrointestinal Function and LPS IL-6 hs-CRP Levels in Patients[J]. HeBei Med, 2018, 24(12): 1991-1994.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.12.014 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I12/1991

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