结核γ-干扰素释放分析试验联合胸腹水ADA检测在结核病诊断中的应用研究

doi:10.3969/j.issn.1006-6233.2018.11.037

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Abstract Objective:To investigate the value of tuberculosis interferon γ (IFN-γ) release assay combined with hydrothorax and ascites adenosine deaminase (ADA) detection in the diagnosis of tuberculosis. Methods: A total of 150 patients with suspected tuberculosis treated in our hospital during the period from December 2016 to February 2017 and 30 healthy volunteers (healthy group) who received physical examination in our hospital during the same period were enrolled in this study. They were divided into the tuberculosis group and the non-tuberculosis group according to the results of percutaneous biopsy. All patients underwent tuberculosis IFN-γ release assay, and samples of hydrothorax and ascites was collected for ADA detection. Results: The positive rate of IFN-gamma release assay, ADA level in pleural and ascites, IFN-gamma release assay and ADA positive rate in pleural and ascites in tuberculosis group were significantly higher than those in non-tuberculosis group and healthy group (P<0.05), but there was no significant difference between non-tuberculosis group and healthy group (P > 0.05). IFN-gamma release assay combined with ADA in pleural and ascites was more effective in the diagnosis of tuberculosis than the single test. Conclusion: The combination of tuberculosis IFN-gamma release assay and detection of ADA level in pleural and ascites can effectively improve the clinical diagnosis of tuberculosis. It is suitable for clinical popularization and application.

Key words： Tuberculosis IFN-γ Release assay Hydrothorax and ascites ADA Diagnosis

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	Articles by authors
	BAI Yun
	WANG Haifeng
	ZHU Hongyan

Cite this article:

BAI Yun,WANG Haifeng,ZHU Hongyan. Application of Tuberculosis Interferon γ-release Assay combined with Hydrothorax and Ascites ADA Detection in the Diagnosis of Tuberculosis[J]. HeBei Med, 2018, 24(11): 1910-1913.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.11.037 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I11/1910

[1] 王红华,冯亚萍,邵全英,等.结核感染酶联免疫法在结核病临床诊断中应用价值研究[J].中华医院感染学杂志,2015,32(6):1224~1226.
[2] 李亮,许绍发.中国结核病诊疗现状及展望[J].中国实用内科杂志,2015,35(8):643~646.
[3] 韩冰,宋其生,于滨,等.胸腔积液ADA/血清ADA和TB-Ab联合检测对结核性胸腔积液的诊断价值[J].山东医药,2015,55(37):49~50.
[4] 蒋海燕,葛锁华.外周血IFN-γ释放试验在结核病诊断中的价值[J].世界中医药,2016,32(6):2119.
[5] 中华医学会结核病学分会.中国结核病分类法[J].中华结核和呼吸杂志,1998(12):716~717.
[6] 何丽美,赵子文.联合检测ADA、CEA和CYFRA21-1对鉴别结核性和恶性胸腔积液的诊断价值[J].热带医学杂志,2015,15(7):914~916.
[7] 彭卫平,王小娟.胸腔积液ADA、IFN-γ联合检测在结核性胸膜炎诊断中的意义[J].山东医药,2015,30(25):56~57.
[8] 张长桂,周兴军,姚晓燕,等.γ-干扰素释放试验和PPD试验在处置学校结核病暴发疫情中的应用分析[J].中国学校卫生,2016,37(2):311~313.
[9] 易斌,曾瑜,李佳萌.胸水ADA、IFN-γ及TB-DNA的联合检测对结核性胸膜炎的诊断价值[J].标记免疫分析与临床,2016,23(11):1341~1343.
[10] 潘丽萍,贾红彦,刘菲,等.γ-干扰素释放试验对不同年龄组疑似肺结核的辅助诊断价值[J].中华结核和呼吸杂志,2015,38(12):1~5.
[11] Yu S N, Jung J, Kim Y K, et al. Diagnostic usefulness of IFN-gamma releasing assays compared with conventional tests in patients with disseminated tuberculosis[J]. Medicine, 2015, 94(28):e1094.
[12] 刘慧梅,张瑞梅,刘加彬,等.胸水IFN-γ、ADA在结核性胸膜炎中的诊断价值研究[J].东南大学学报(医学版),2016,35(6):985~988.
[13] 冯晓朦,王晶莹,时景伟,等.血清ADA水平和T-spot.TB联合检测在肺结核诊断中的应用[J].吉林大学学报(医学版),2016,42(2):306~310.