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| Analysis on the Curative Effect of Nasal Irrigation Combined with Mometasone Furoate Aqueous Nasal Spray in treatment of Patients with Allergic Rhinitis and the Influence on Serum IL-5 and Osteopontin |
| YANG Liang, ZHANG Jianwei, NI Ze, et al |
| Nanjing Gulou Hospital Affiliated to Nanjing University Medical College, Jiangsu Suqian 223800, China |
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Abstract Objective: To analyze the curative effect of nasal irrigation combined with Mometasone Furoate Aqueous Nasal Spray in treatment of patients with allergic rhinitis and the influence on serum interleukin-5 (IL-5) and osteopontin (OPN). Methods: 102 patients with allergic rhinitis were divided into control group (n=51) and experimental group (n=51) by lottery, the control group was treated with mometasone furoate nasal spray, experimental group treated with nasal irrigation joint Mometasone Furoate Aqueous Nasal Spray. IL-5, IL-10, IL-17, OPN, immunoglobulin-E (IgE), eosinophil (Eos), airway viscosity resistance R5 and R20, resonance frequency (Fres), signs and symptoms score, curative effect and adverse reactions of two groups were compared. Results: After treatment, the IL-5,IL-17, OPN, IgE, Eos, R5, R20, Fres OF experimental group was lower than the control group (P<0.05). The IL-10 of experimental group was higher than the control group (P<0.05). The signs and symptoms score, efficient of experimental group was better than that of control group (P<0.05). The adverse reactions was no differences between the two groups (P>0.05). Conclusion: The method of nasal irrigation combined with mometasone furoate aqueous nasal spray in treatment of patients with allergic rhinitis has high safety and curative effect. It can reduce the levels of serum IL- 5 and osteopontin.
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2018, Vol. 24 
