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| Clinical Efficacy of Mecobalamin Combined with Norfloxacin in the treatment of Gestational Diabetes Mellitus and its Effect on Serum RBP4 FGF21 and Nesfatin-1 |
| FAN Xiaojun, WANG Jing |
| Baoji City Maternal and Child Health Hospital, Shaanxi Baoji 721000, China |
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Abstract Objective: To study curative efficacy of mecobalamin combined with insulin aspart flexpen in treatment of gestational diabetes mellitus and effects on serum retinol-binding protein 4(RBP4), fibroblast growth factor 21(FGF21), feeding inhibition factor -1(Nesfatin-1) levels. Methods: 100 patients of gestational diabetes mellitus who received therapy from October 2016 to October 2017 in our hospital were selected as research objects. According to random number table, all the patients were divided into the observation group (n=50) and the control group (n=50). The control group was treated with insulin aspart flexpen, while the observation group was combined with mecobalamin, they were treated with 7d for 1 courses, continuous treatment for 3 courses. Results: After treatment, fasting blood glucose (FPG) and 2-hour postprandial blood glucose (2-hour PBG) in both groups were significantly lower than those before treatment (P<0.05); FBG and 2-hour PBG in observation group were significantly lower than those in control group (P<0.05). After treatment, the levels of RBP4, FGF21 and Nesfatin-1 in serum of the two groups were significantly lower than those before treatment (P<0.05). The levels of RBP4, FGF21 and Nesfatin-1 in the observation group were significantly lower than those in the control group [(21.20+2.47) ug/mL VS (26.94+3.24) ug/mL, (101.39+13.52) ng/L VS (127.34+14.50) ng/L, (1.38+0.20) ug/L VS (1.67+0.27). G/L] (P<0.05); The total incidence of hypoglycemia, nausea, vomiting and hyperosmotic coma in the observation group was 8.00% (4/50), significantly lower than that in the control group (24.00% (12/50) (P<0.05). Conclusion: Mecobalamin combined with norfloxacin has significant therapeutic effect on gestational diabetes mellitus. It can effectively reduce blood glucose and the expression of RBP4, FGF21 and Nesfatin-1 in serum, and improve the adverse maternal and infant outcomes. It is safe to use Mecobalamin combined with norfloxacin.
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2018, Vol. 24 
