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| Diagnostic Value of Ankle-brachial Index Combined with Vibrating Perception Threshold in Type 2 Diabetes Mellitus Complicated with Lower Extremity Atherosclerotic Disease |
| LUO Lingguang, LONG Xinping |
| Laibin People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Laibin 546100, China |
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Abstract Objective: To explore the diagnostic value of ankle brachial index (ABI) combined with vibration perception threshold (VPT) in type 2 diabetes mellitus (DM) complicated with lower extremity atherosclerotic disease. Methods: A total of 119 type 2 diabetes mellitus patients with PAD were selected and randomly divided into two control group (ABI≥0.9; VPT≤10 V) 56 cases and observation group (ABI<0.9; VPT>10V) 63 cases. The ABI was detected by ultrasonic flow meter, and The VPT was detected by digital vibration perception threshold detector,and the levels of TC, TG, HDL-C, LDL-C, FBG, HbA1c, uric acid and ALB were detected by automatic biochemical analyzer. Results: The level of ABI in the observation group was lower than that in the control group, and the VPT level was higher in the observation group than that in the control group (t=13.45, 14.67, P<0.05); The level of LDL-C in the observation group was higher than that in the control group (t=15.32, P<0.05); The level of uric acid in the observation group was higher than that in the control group (t=15.67, P<0.05); The age, course of disease, LDL-C and uric acid were negatively correlated with ABI and positively correlated with VPT, with statistic difference (P<0.05); Age, duration of disease, LDL-C, and uric acid were risk factors for type 2 diabetes mellitus with LEAD (regression coefficients =1.43, 1.61, 1.71, 1.45, P<0.05);ABI ≤ 0.9 is the gold standard for the diagnosis of type 2 diabetes mellitus combined with lower extremity atherosclerotic disease. The diagnostic criteria are VPT>10 V, sensitivity is 75.9%, specificity is 84.8%, false negative rate is 24.0%, false positive rate 15.2%, correct index 0.61, positive likelihood ratio 4.99, negative likelihood ratio 0.28, Kappa consistency analysis, value is 0.60. Conclusion: In type 2 diabetic patients with lower extremity atherosclerotic disease, ankle brachial index decreased and vibration perception threshold increased, which were closely related to the risk factors such as age, course of disease, LDL-C, uric acid.
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2018, Vol. 24 
