孕酮β-hCG联合CA125在先兆流产中的检测意义

doi:10.3969/j.issn.1006-6233.2018.11.003

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Abstract Objective: To analyze the clinical value of progesterone, chorionic gonadin (β-hCG) and glycoprotein 125 (CA125) detection in patients with threatened abortion. Methods: 113 cases of threatened abortion admitted in our hospital from May 2015 to November 2016 were divided into 65 cases of threatened abortion continuing pregnancy group and 48 cases of inevitable abortion group according to pregnancy outcome. 53 normal pregnancies were selected at the same time. The levels of progesterone, beta-hCG and CA125 were measured by radioimmunoassay. The serum levels of progesterone, beta-hCG and CA125 in each group were observed and compared. The possible risk factors of threatened abortion were identified. The relationship between P, beta-hCG and CA125 and threatened abortion was analyzed by multiple logistic regression and ROC curve. Results: The levels of progesterone and beta-hCG in the inevitable abortion group were lower than those in the threatened abortion group and were lower than those in the normal pregnancy group (11.70 [1.26], (24.09 [3.19], (26.70 [4.20] mg / mL, (1879.53 [220.18], (6982.11 [876.10], (7035.96 [965.12] mU / ml. CA125 was higher in threatened abortion group than in continuing pregnancy group and higher than in normal pregnancy group (57.88 [8.96], (27.63 [3.41], (19.40 [2.76] U/mL. The difference was statistically significant (P<0.05). Logistic regression analysis showed that serum progesterone, beta -hCG and CA125 levels were independent factors influencing the occurrence of threatened abortion. ROC curve showed, area under progesterone curve was 0.723 (95%CI was 0.628~0.819), and the sensitivity and specificity were 0.406 and 0.761. The area under the β-hGG curve was 0.513 (95%CI was 0.406~0.620), and the sensitivity and specificity was 0.653 and 0.672. Area under curve of CA125 was 0.812 (95% CI 0.737~0.888), the sensitivity and specific degree was 0.782 and 0.567, the joint detection area under the curve was 0.857 (95% CI was 0.790~0.924), sensitive and specific degree was 0.663 and 0.716 respectively, the joint detection area under curve is significantly higher than individual indicators. Conclusions: Progesterone, beta-hCG and CA125 can objectively reflect the state of pregnancy, predict threatened abortion, improve clinical diagnosis, thus conducive to clinical treatment.

Key words： Threatened abortion Progesterone Human chorionic gonadotropin Glycoprotein 125

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	ZHANG Yan
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ZHANG Yan,et al. Significance of Progesterone beta -hCG combined with CA125 in Threatened Abortion[J]. HeBei Med, 2018, 24(11): 1769-1772.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.11.003 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I11/1769

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