生血宁片治疗维持性血液透析患者肾性贫血的临床观察

doi:10.3969/j.issn.1006-6233.2017.11.043

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Abstract Objective: To observe the clinical efficacy of Shengxuening tablets to improve the law to maintain iron metabolism in hemodialysis patients with renal anemia and erythropoietin and its synergistic effect. Methods: 60 cases uremic patients with renal anemia selected as the research object, randomly divided into Shengxuening group and succinic acid ferrous group, 30 cases in each group. The patients of shengxuening group were given oral Shengxuening tablets, and oral ferrous succinate group was given Ferrous Succinate Tablets. In accordance with the guidelines, the patients of 2 groups were given the recommended dose individualized combination of erythropoietin treatment. After 16-weeks treatment, the clinical curative effect of the patients of 2 groups were observed and the changes of hemoglobin, hematocrit, serum ferritin and transferrin saturation were recorded before and after treatment in 2 groups. Meanwhile, the adverse reactions in the 2 groups were monitored. Results: After 16 weeks of treatment, the hemoglobin, hematocrit, serum ferritin, transferrin saturation of the 2 groups were increased compared with before treatment, the difference was statistically significant (P < 0.05). However, after treatment, the hemoglobin, hematocrit, serum ferritin, transferrin saturation of Shengxuening group was significantly higher than that of ferrous succinate group, the difference was statistically significant (P < 0.05). Compared with ferrous succinate group, Shengxuening group of adverse reaction is less. Conclusion: Compared with ferrous succinate group, Shengxuening can effectively supplement renal anemia in patients with uremia for iron, and less adverse reactions of blood safety.

Key words： Shengxuening Renal anemia Hemodialysis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.11.043 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I11/1905

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