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| Effects of Tacrolimus combined with Huaiqihuang Granule on Primary Nephrotic Syndrome in Children and its Influence on Serum VEGF TGF-β1 IL-1β and IFN-γ |
| ZHOU Wubin |
Huangshi Central Hospital, Hubei Huangshi 435000, China
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Abstract Objective: To study the efficacy of tacrolimus combined with Huaiqihuang granule in children with primary nephrotic syndrome and the effects of serum vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), interleukin 1β (IL-1β), interferon-γ (IFN-γ). Methods: From September 2016 to March 2017, 80 children with primary nephrotic syndrome were selected and divided into control group and experimental group, 40 cases in each group. On the basis of routine treatment, the control group was treated with tacrolimus, and the experimental group was treated with tacrolimus combined with Huaiqi Huang granules for 12 weeks. The clinical efficacy, serum levels of VEGF, TGF-beta 1, IL-1beta, IFN-gamma and adverse reactions were observed and compared between the two groups. Results: At the 4th week, the time of edema subsided and urinary protein was shorter than that of the control group, the difference was statistically significant (P <0.05). The blood cholesterol level of the experimental group was slightly higher than that of the control group (P <0.05). At the 12th week, the effective rate of the experimental group was 95.00%, which was higher than that of the control group (77.50%). The level of serum albumin in the experimental group was significantly higher than that in the control group (P<0.05). The level of serum albumin was slightly higher than that of the control group, the difference was not statistically significant (P>0.05). Before treatment, the levels of serum VEGF, TGF-β1, IL-1β and IFN-γ were not statistically significant (P>0.05). After treatment, the levels of serum VEGF, TGF-β1, IL-1β and IFN-γ were decreased in both groups (P<0.05). The difference between the two groups was significant (P<0.05). The total adverse reaction rate was 15.00% in the experimental group, which was lower than that in the control group, of which was 35.00% (P <0.05). Conclusion: The clinical effect of tacrolimus combined with Huaiqihuang granule in the treatment of children with primary nephrotic syndrome is better, which can effectively reduce the serum levels of VEGF, TGF-β1, IL-1β, IFN-γ level.
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2018, Vol. 24 
