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| Analysis on Risk Factors of Premature Ovarian Failure in Women of Middle Age |
| ZHANG Xiaojing, DING Feng, LI Haijiao |
| Global Care Women's and Children's Hospital, Beijing 100022, China |
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Abstract Objective: To investigate the risk factors of premature ovarian failure (POF) in women of middle age. Methods: 100 cases of premature ovarian failure women who received treatment in our hospital from February 2015 to February 2017 were selected as the subjects, and 100 healthy women were selected as the control group. The differences of ABO blood group, menstrual cycle and type A behavior and personality between the two groups were observed, and the factors influencing the incidence of POF were analyzed. Results: The irregular menstrual cycle, type A personality and BMI was 24kg/m2 higher incidence of premature ovarian failure (χ2=42.473, 15.394, 8.515, P<0.05), and different age, the incidence of POF in female ABO blood group had no significant difference; Age, menstrual cycle, ABO blood type, type A personality and BMI as independent variables, the occurrence of premature ovarian failure as the dependent variable, Logistic regression analysis, the results in menstrual cycle regularity and type A personality into the regression equation, the OR values were 5.361 and 4.985; The incidence of POF in patients with premature ovarian failure is positively correlated with menstrual cycle and type A behavioral personality (r=0.613, 0.598, P=0.012, 0.008), but not significantly related to ABO blood type. Conclusion: Irregular menstrual cycle and type A personality are risk factors for premature ovarian failure in women of the right age.
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[1] Perez-Andújar A, Newhauser W D, Taddei P J, et al. The predicted relative risk of premature ovarian failure for three radiotherapy modalities in a girl receiving craniospinal irradiation[J]. Physics in Medicine and Biology,2013,58(10):3107~3123.
[2] Cordts E B, Santos A A, Peluso C, et al. Risk of premature ovarian failure is associated to the PvuII polymorphism at estrogen receptor gene ESR1[J]. Journal of Assisted Reproduction and Genetics,2012,29(12):1421~1425.
[3] 付天芳,王瑞.卵巢早衰女性性生活状况调查及健康教育对策研究[J].中国性科学,2016,(8):42~45.
[4] 冯暄,郝胜菊,张庆华,等.引起卵巢早衰相关遗传因素的研究进展[J].中国优生与遗传杂志,2015,(10):132~135.
[5] 曹晓静,王小云.卵巢早衰易感基因研究[J].长春中医药大学学报,2014,(6):1155~1157.
[6] He M, Shu J, Huang X, et al. Association between estrogen receptora gene (ESR1) PvuII (T/C) and XbaI (A/G) polymorphisms and premature ovarian failure risk: evidence from a meta-analysis[J]. Journal of Assisted Reproduction and Genetics,2015,32(2):297~304.
[7] Oktay K, Bedoschi G. Oocyte cryopreservation for fertility preservation in postpubertal female children at risk for premature ovarian failure due to accelerated follicle loss in turner syndrome or cancer treatments[J]. Journal of Pediatric and Adolescent Gynecology,2014,27(6):342~346.
[8] 赵倩,叶宸,李文.卵巢早衰的研究现状与进展[J].生殖与避孕,2014,34(01):59~64.
[9] 黎凤鸣.特发性卵巢早衰发病因素的logistic回归分析[J].现代诊断与治疗,2016,27(2):209~210.
[10] 王希路,杨菁.80例特发性卵巢早衰相关危险因素调查与分析[J].华南国防医学杂志,2015,(3):211~214.
[11] 杨伟,李琴,李佳.卵巢早衰与卵巢储备功能下降的相关因素分析[J].宁夏医学杂志,2015,(4):327~329. |
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2018, Vol. 24 
