AbstractObjective: To investigate the effect of Tangwei capsule on lipid metabolism, vascular endothelial function and microcirculation in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 200 patients with T2DM were randomly divided into the control group (100 cases) and the observation group (100 cases). The control group were treated with oral hypoglycemic agents or insulin, and the observation group were additionally treated with Tangwei capsule. Both groups were treated for 12 weeks. The levels of glucose and lipid metabolism, vascular endothelial function and microcirculation were compared between the two groups before and after treatment. Results: After the treatment, the insulin resistance (IR), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels in the observation group were lower than those in the control group, while the high-density lipoprotein cholesterol (HDL-C) level was higher than that in the control group (P < 0.05). There were no significant differences in fasting blood glucose (FBG), postprandial 2h plasma glucose (2hPG) and glycosylated hemoglobin (HbA1c) between the two groups after treatment (P > 0.05). After treatment, the nitric oxide (NO) and endothelium dependent vasodilation (FMD) were higher, and plasma endothelin -1 (ET-1) was lower in the obsercation group than the control group (P < 0.05). After treatment, the diameters of afferent loop, efferent loop and top of loop were larger in the observation group than the control group, and the number of tube loop malformation was smaller than that in the control group (P < 0.05). Conclusion: Compared with routine hypoglycemic therapy, Tangwei capsule combined with routine hypoglycemic therapy has more advantages in regulating abnormal lipid metabolism and vascular endothelial function and relieving microcirculation disturbance in patients with T2DM.
BAI Jianle,et al. Effect of Tangwei Capsule on Lipid Metabolism, Vascular Endothelial Function and Microcirculation in Patients with Type 2 Diabetes Mellitus[J]. HeBei Med, 2017, 23(11): 1888-1891.
[1] 宋俊华,何霞,陈敏,等.长沙地区糖尿病流行病学调查[J].医学临床研究,2015,32(12):2324~2326. [2] 郝运,何金鹏,余学锋,等.2型糖尿病周围神经病变的危险因素研究[J].内科急危重症杂志,2016,22(4):259~261. [3] 龚兰,陈明,魏娴,等.高效液相-电喷雾串联质谱法测定动物肌肉组织中的糖皮质激素[J].分析化学,2016,44(1):74~80. [4] Organization W H. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a world health organisation collaborations[J].Diabetic Medicine, 1999,15(7):539. [5] 徐杰,王艳.2型糖尿病患者的血脂水平、血清胎球蛋白A与糖尿病肾病的相关性研究[J].湖南师范大学学报(医学版),2016,13(4):55~57. [6] 王燕.采用胰岛素泵短期治疗改善2型糖尿病合并高脂血症患者胰岛素抵抗和β细胞功能的效果观察[J].中国基层医药,2012,19(12):1881~1882. [7] 吴志明,叶飞,尤威,等.微循环阻力指数对2型糖尿病患者冠状动脉微循环障碍的评价作用[J].中国临床医学,2014,21(4):400~402. [8] 刘毅,江腾春,傅强,等.黄芪对糖尿病患者血清胰岛素样生长因子-1、颈动脉内膜中层厚度的影响[J].实用医学杂志,2015,31(17):2907~2909. [9] 于晓娜,崔波,任贵兴,等.西洋参多糖的研究进展[J].食品科学,2014,35(9):301~305. [10] 崔波,高华荣.黄精多糖药理作用研究进展[J].山东医药,2014,54(34):101~102. [11] 李琼,叶小利,曾红,等.天花粉凝集素的提取工艺及降糖活性研究[J].中药材,2012,35(3):475~479. [12] 王霜,赵兴冉,章雷,等.葛根黄连有效成分降糖作用对比及其血清化学研究[J].中药药理与临床,2015,31(1):165~168. [13] 马航,胡慭然,邹宗尧,等.黄连生物碱降糖作用研究及构效关系初探[J].中国药理学通报,2015,31(11):1575~1579.
2017, Vol. 23 
