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| Clinical Efficacy Observation of Leuprolide Acetate Combined with Tibolone in the treatment of Endometriosis |
| CHEN Rong, WANG Jun, LIU Yuehe |
| 3201 Hospital Affiliated to Xi'an Jiaotong University, Shaanxi Hanzhong 723000, China |
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Abstract Objective: To investigate the clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis. Methods: 80 patients with endometriosis admitted from October 2015 to October 2016 were randomly divided into two groups: leuprolide acetate group and leuprolide acetate group Boulong,. The clinical indicators, bone mineral density, overall treatment effect and Kupperman score of the two groups were compared. Results: The levels of 24wFSH (3.04 ± 0.53), LH (4.41 ± 0.73) and E2 (31.45 ± 6.33) in the combined group were significantly higher than those in the leuprolide group (2.38 ± 0.40,3.45 ± 0.70 , 25.78 ± 5.19), BGP (16.60 ± 4.17) and CA125 levels (13.27 ± 4.04) were significantly lower than those in the leuprolide group (24.17 ± 5.89 and 18.77 ± 4.60) The level of lumbar BMD at 6 months (1.085 ± 0.060) and 12 months after lumbar spine withdrawal (1.082 ± 0.061) were significantly higher than those in leuprolide group (1.035 ± 0.062,1.050 ± 0.051,1.054 ± 0.050) ; The total effective rate (87.5%) was significantly higher than that of leuprolide group (70%); after treatment, hot flashes, sweating value (5.90 ± 0.76), vulvar vaginal discomfort value (1.90 ± 0.55) (0.60 ± 0.18) and Kupperman score (7.94 ± 1.80) were lower than those in the leuprolide group (7.12 ± 0.88, 3.33 ± 1.08, 1.05 ± 0.42 and 10.77 ± 2.35 respectively), the difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis is significant, which can improve the safety and has reference value.
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2018, Vol. 24 
