|
|
|
| Effects of Standard Large Trauma Craniotomy combined with Mild Hypothermia on Postoperative NIHSS Score and Serum S-00β and MBP Levels in Patients after Operation with Severe Craniocerebral Injury |
| FENG Tao, HAN Bing, YE Kaihua |
| The Second People's Hospital of Dongying, Shandong Dongying 257335, China |
|
|
|
|
Abstract Objective: To investigate the effects of standard large trauma craniotomy combined with mild hypothermia on postoperative NIHSS score and serum astrocyte protein (S-100β) and myelin basic protein (MBP) in patients with severe craniocerebral injury. Methods: From April 2016 to November 2017, 72 patients with severe craniocerebral injury were treated in the Department of Neurosurgery at the second people's Hospital in Dongying. The random digital table method was divided into the control group (n=36) and the study group (n=36). The control group was treated with standard large trauma craniotomy, while the study group was treated with standard large trauma craniotomy plus mild hypothermia treatment. 1 month after admission and 1 month after operation, the scores of two groups of nerve function defect (NIHSS), intracranial pressure level (1d, 2d, 3d), and the changes of serum S-100 beta and MBP levels at admission and first d after operation were compared, and the incidence of complications in two groups were compared. Results: The NIHSS scores in the two groups after treatment were lower than those before treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05); The intracranial pressure of the two groups at 1d, 2d and 3d after treatment was lower than before treatment, and the study group was lower than that of the control group at each time period, the difference was statistically significant (P <0.05); The levels of serum S-100β and MBP in the two groups after treatment were lower than those before treatment, the study group was lower than the control group, the difference was statistically significant (P <0.05); The incidence of complications in the study group was significantly lower than that of the control group (P <0.05). Conclusion: Treatment of severe craniocerebral injury using standard large trauma craniotomy combined with mild hypothermia gets a significant effect, which can effectively reduce intracranial pressure, improve neurological function, reduce serum S-100β, MBP levels, and the low incidence of complications , with higher security, worthy of promotion.
|
|
|
|
|
|
[1] 李耀泽,侯书杨,马龙君.标准外伤大骨瓣开颅术联合亚低温治疗重型颅脑损伤的效果[J].中国实用神经疾病杂志,2017,20(6):64~66.
[2] Yamamoto T,Mori K,Maeda M.Assessment of prognostic factors in severe traumatic brain injury patients treated by mild therapeutic cerebral hypothermia therapy[J].Neurological Research,2013,24(8):789~795.
[3] 马君实.亚低温辅助治疗对急性重型颅脑损伤患者外周血NSE、NO和CRP水平的影响[J].中国老年学杂志,2014,34(18):5103~5105.
[4] 陈孝平,汪建平.外科学[M].第8版.北京:人民卫生出版社,2013.196~208.
[5] 柯于勇,刘军.标准外伤大骨瓣开颅术联合亚低温治疗重型颅脑损伤的临床研究[J].中国实用神经疾病杂志,2016,19(2):29~31.
[6] 黄锦丰,凌国源,玉石,等.标准外伤大骨瓣开颅术联合亚低温治疗重型颅脑损伤疗效观察[J].牡丹江医学院学报,2016,37(3):10~12.
[7] 徐卫旭.大骨瓣减压术联合脑局部亚低温治疗重型颅脑损伤临床效果[J].江苏医药,2013,39(4):446~447.
[8] 宋晓洁,冯伟平,韩雪娇,等.血清IL-6及S-100B水平对颅脑损伤严重程度和预后评估的临床意义[J].现代生物医学进展,2016,16(20):3883~3886.
[9] 史博.标准外伤大骨瓣开颅术联合超早期亚低温治疗重型颅脑损伤的临床研究[J].国际医药卫生导报,2017,23(3):326~330. |
| [1] |
. [J]. 河北医学, 2017, 23(8): 1319-1322. |
|
|
|
|
2018, Vol. 24 
