重组人脑钠肽联合心脉隆注射液对心脏瓣膜置换术患者血清Apelin-12 D-二聚体及心功能的影响研究

doi:10.3969/j.issn.1006-6233.2018.08.005

Abstract
Figure/Table
References
Related Citation (0)

Download: PDF (1346 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To study the influence of recombinant human brain natriuretic peptide combined with Xinmailong injection on serum Apelin-12, D-dimer and cardiac function in patients with cardiac valve replacement. Methods: 80 patients with mitral valve replacement who received therapy from Aug. 2015 to Aug. 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=40) and the control group (n=40), they were given routine treatment after operation, the control group was treated with Xinmailong injection, while the observation group was combined with recombinant human brain natriuretic peptide. The perioperative condition, serum N-terminal pro brain natriuretic peptide (NT-proBNP), serum Apelin-12, D-dimer, left ventricular ejection fraction (LVEF), creatine kinase isoenzyme (CK-MB), troponin I (cTnI) and incidence of postoperative adverse events were compared between the two groups. Results: The mechanical ventilation time, ICU time and the hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05). The NT-proBNP of two groups were significantly lower than those before the operation (P<0.05), and the NT-proBNP in the observation group was significantly lower than those in the control group (P<0.05). The serum Apelin-12, D-dimer of two groups were significantly higher than those before the operation (P<0.05), and the serum Apelin-12, D-dimer in the observation group was significantly lower than those in the control group (P<0.05); after the operation, the LVEF of two groups were significantly lower than those before the operation, and the CK-MB and cTnI were significantly increased (P<0.05), and the LVEF in the observation group was significantly higher than those in the control group, the CK-MB and cTnI was significantly lower than those in the control group (P<0.05); 1 months after operation, there was no significant difference in the incidence of infection and hypoglycemia between the two groups (P>0.05), the incidence of atrial fibrillation and thrombus in the observation group was significantly lower than those in the control group 2.50%(1/40)vs 15.00%(6/40),2.50%(1/40)vs 17.50%(7/40) (P<0.05). Conclusion: The effect of recombinant human natriuretic peptide combined with heart injection after cardiac valve replacement is significant, and it has protective effect on cardiac function, and can reduce the incidence of atrial fibrillation and thrombus after operation. The internal mechanism may be related to the effective control of the elevation of serum Apelin-12 and D- two polymer.

Key words： Cardiac valve replacement Recombinant human brain natriuretic peptide Xinmailong injection

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HUANG Lihua
	HOU Xiuwei
	LI Wei

Cite this article:

HUANG Lihua,HOU Xiuwei,LI Wei. Effect the Study of Recombinant Human Brain Natriuretic Peptide Combined with Xinmailong Injection on Serum Apelin-12 D-dimer and Cardiac Function in Patients with Cardiac Valve Replacement[J]. HeBei Med, 2018, 24(8): 1249-1253.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.08.005 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I8/1249

[1] 温雅,蒋晓莲,白阳静,等.心脏瓣膜置换术后患者生存质量研究现状[J].华西医学,2016,31(06):1137-1141.
[2] Schoenenberger AW, Moser A, Bertschi D, et al. Improvement of risk prediction after transcatheter aortic valve replacement by combining frailty with conventional risk scores[J]. JACC Cardiovasc Interv, 2018, 11(4): 395~403.
[3] Zhang LT, Long YL, Yang J, et al. Association between D-dimer levels and clinical events in patients with mechanical heart valve replacement under oral anticoagulation therapy[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2017, 45(10): 852~856.
[4] Topuz M, Oz F, Akkus O, et al. Plasma apelin-12 levels may predict in-hospital major adverse cardiac events in ST-elevation myocardial infarction and the relationship between apelin-12 and the neutrophil/lymphocyte ratio in patients undergoing primary coronary intervention[J]. Perfusion, 2017, 32(3): 206~213.
[5] 刘红旭,朱明军,毛静远,等.规范应用心脉隆注射液治疗慢性心力衰竭的专家共识[J].中国中西医结合杂志,2016,36(03):280~284
[6] 韩强,张华勇,王晓进.rh-BNP缺血后处理对心脏瓣膜置换术心肌保护作用的临床研究[J].重庆医学,2016,45(32):4542~4546.
[7] McCann GP, Singh A. Revisiting reverse remodeling after aortic valve replacement for aortic stenosis[J].Am Coll Cardiol, 2018, 71(8): 872~874.
[8] 张登沈,梁贵友,刘达兴,等.心脏瓣膜置换术后早期死亡原因及相关因素分析[J].临床心血管病杂志,2015,31(08):874~878.
[9] Liu Y, Wang Z, Xiao W, et al. Use of gated myocardial perfusion imaging to assess clinical value of Xinmailong injection in chronic congestive heart failure[J].Tradit Chin Med, 2014, 34(5): 555~559.
[10] 张家美,尚亚东,吴晓蓉,等.心脉隆注射液治疗慢性心力衰竭临床疗效的Meta分析[J].中国全科医学,2014,17(12):1388~1393.
[11] 冯雪,张海涛.重组人脑利钠肽治疗急性心力衰竭疗效和安全性的Meta分析[J].中国现代医药杂志,2016,18(03):7~12.
[12] Abuzaanona A, Lanfear D. Pharmacogenomics of the natriuretic peptide system in heart failure[J]. Curr Heart Fail Rep, 2017, 14(6): 536~542.
[13] Topuz M, Cosgun M, et al. Effect of spironolactone on plasma apelin-12 levels in patients with chronic systolic heart failure[J]. Acta Cardiol Sin, 2016, 32(6): 690~697.
[14] 吴鲁卿, 谢翠贤,徐静.Apelin-12检测在瓣膜置换术中的临床价值[J].中国综合临床,2016,32(11):996~999.
[15] Chen TT, Jiandong-Liu, Wang G, et al. Combined treatment of ulinastatin and tranexamic acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery[J]. Heart Surg Forum, 2013, 16(1): 38~47.