胸腔镜手术对胸中下段早期食道癌患者IgA IgG IgM及生活质量的影响

doi:10.3969/j.issn.1006-6233.2019.02.020

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Abstract Objective: To investigate the effects of thoracoscopic surgery on IgA, IgG, IgM and quality of life in patients with early and middle thoracic esophageal cancer, and to analyze the clinical effects. Methods: Eighty-four patients with lower thoracic esophageal cancer who were treated in our hospital from November 2015 to November 2016 were enrolled. The patients were divided into observation group (n=43) and control group (n=41) by simple random grouping. The control group underwent thoracotomy and the observation group underwent thoracoscopic surgery. Compare the operation time, intraoperative blood loss, hospitalization time, complete resection rate, compare the preoperative and postoperative immune function indexes immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), The quality of life index scores were changed. The 1st, 3rd, and 5th year survival rates were recorded. The incidence of complications such as chylothorax, pneumothorax, recurrent laryngeal nerve injury, anastomotic leakage, and arrhythmia were recorded. Results: The operation time and hospitalization time of the observation group were shorter than those of the control group (P<0.05). The intraoperative blood loss was lower in the observation group than in the control group (P<0.05). The complete resection rate was 93.33% in the observation group and 69.78% in the control group. The observation group was higher than the control group (P<0.05). After operation, the immune function indexes of IgA, IgG and IgM were decreased in the two groups, but the observation group was significantly higher than the control group (P<0.05). After operation, the quality of life indicators such as physical function, social function, material life and overall health of the two groups were improved, but the observation group was significantly higher than the control group (P<0.05). After the operation, the patient was given a 5-year telephone call. After follow-up, the results showed that the 1-year survival rate of the observation group was 93.02%, the 3-year survival rate was 81.39%, and the 5-year survival rate was 74.41%, which was significantly higher than the control group of 68.29%, 58.53%, and 48.78% (P<0.05). During the treatment, complication of chylothorax, pneumothorax, recurrent laryngeal nerve injury, anastomotic leakage and arrhythmia occurred in both groups. The total incidence of 8.89% in the observation group was significantly lower than that in the control group (34.88%) (P<0.05). Conclusion: Thoracoscopic surgery for patients with early and middle thoracic esophageal cancer can shorten the length of hospital stay, improve the surgical resection, reduce the immune function of the body, improve the quality of life, postoperative survival rate, and high safety. It is safe and effective.

Key words： Esophageal cancer Resection effect Thoracoscopy Early stage

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.02.020 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I2/250

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