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Changes of Related Factors of Gastrointestinal Motility Disorders in Rabbit Models of Severe Acute Pancreatitis |
WANG Gang, HAN Junling, WANG Fang, et al |
The First Hospital of Qinhuangdao, Hebei Qinhuangdao 066000, China |
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Abstract Objective: To study the related factors of gastrointestinal motility disorder in rabbits with severe acute pancreatitis. Methods: 30 New Zealand SPFrabbits were randomly divided into control group and experimental group, 15 rabbits in each group. The rabbits in the experimental group were established by injection of sodium taurocholatethrough pancreatic duct, and the rabbits in the control group were operated through the experimental group, but injected with equal volume distilled water.After 24h, the general condition of the rabbit's abdominal cavity was observed, the gastrointestinal transmission index (TI) was calculated, and the serum levels of GAS, MTL, SP, VIP, CCK, TNF- a, IL-1 and IL-6 were detected. The pathological sections of the pancreas were made, under the microscope, and the pathological score was observed. Results:In the experimental group, a large number of turbidity ascites, many saponification spots, large hemorrhage and necrosis of the pancreas, obvious hyperemia and edema of the gastrointestinal tract accompanied by partial necrosis were found in the abdominal cavity. The widening of the interleaf space of the pancreas tissue, the edema of the cells, the necrosis of some acinar cells and a large number of inflammatory cells infiltrated in the experimental group.The TI in the experimental group was lower than the control group, and PSP was significantly higher(P<0.05); The concentrations of GAS, SP and VIP in the experimental group were higher, and the concentration of MTL、CCK was lower(P<0.05). The concentrations of TNF-α, IL-1 and IL-6 in the experimental group were higher(P<0.05).Conclusion: SAP white rabbits have gastrointestinal motility disorders, which are closely related to the abnormal expression of gastrointestinal hormones and inflammatory factors.
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[1] 胡洪生,沈丰,吴红伟,等.治疗性内镜辅助下逆行胰胆管造影术治疗胆源性胰腺炎疗效及对患者血清CRP、ET-1和TNF-α的影响[J].胃肠病学和肝病学杂志,2018,(3):329~332. [2] 叶美玲,彭燕.急性重症胰腺炎肠道动力障碍机制的研究进展[J].医学综述,2016,22(20):4039~4042. [3] 刘龙飞,何俊君.丹参在重症急性胰腺炎大鼠结肠壁神经丛ACH、VIP、NOS表达与胃肠动力关系研究[J].辽宁中医杂志,2016,43(7):1498~1501. [4] 徐汇,曾悦.重症急性胰腺炎中肠屏障功能障碍机制的研究进展[J].世界华人消化杂志,2016,24(17):2661~2666. [5] 杨军,顾元龙,姜东林,等.重症急性胰腺炎患者早期肠屏障失功能与炎症反应[J].肝胆胰外科杂志,2014,26(3):177~180. [6] 郭徽,张荣荣,朱世峰,等.针刺调控急性胰腺炎胃肠动力障碍的研究进展[J].针灸临床杂志,2013,29(5):88~90. [7] 朱美冬,罗运权.中西医治疗重症急性胰腺炎的研究进展[J].临床肝胆病杂志,2017,33(1):188~193. [8] 刘芳,姚树坤,王慧芬,等.急性胰腺炎患者胃肠动力紊乱与胃肠激素的关系分析[J].现代消化及介入诊疗,2016,21(3):426~428. |
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