|
|
|
| Relationship between Neurobehavioral Behavior of Simple Obesity and Serum IGF-1 and GH levels in Preschool Children |
| HUANG Chun, TAN Chi, WANG Xin, et al |
| Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Guangxi Nanning 530011, China |
|
|
|
|
Abstract Objective: To study the incidence of neural behavioral problems and the changes of serum insulin growth factor-1 (IGF-1) and growth hormone (GH) levels of preschool children with simple obesity, and to explore the correlations between neural behavioral of children with simple obesity with the serum IGF-1 and GH. Methods: 120 preschool children aged 4-6 years in a certain urban area of Nanning, 60 children with body weight exceeding 20% of standard weight were selected as obese group, and 60 children with normal weight were used as normal group. The Achenbach Child Behavior Checklist (CBCL) was used to assess the psychological and behavioral abilities of the children, detection of serum IGF-1 and GH levels in children by enzyme-linked immunosorbent assay (ELISA), the relationships between CBCL score with serum IGF-1 and GH were analyzed. Results: The incidence rate of abnormal neural behavioral problems in obese group was significantly higher than that in the normal group (χ2=10.159, P=0.001), the incidence rate of neural behavioral abnormalities in children with severe obesity was significantly higher than that in children with mild to moderate obesity (χ2=4.516, P=0.034); the CBCL total score of boys in obesity group was significantly higher than that of boys in normal group (P<0.05), the CBCL total score of girls was significantly higher than that of girls in the normal group (P<0.05); the serum IGF-1 levels in obese children were significantly higher than those in the normal group (P<0.05), serum GH levels were significantly lower than those in normal group (P<0.05), the heavier the level of obesity, the higher the level of serum IGF-1, the lower the level of GH; the CBCL score is significantly positively correlated with the serum IGF-1 in obese group (r=0.622, P=0.000), was negatively correlated with serum GH level (r=-0.489, P=0.012). Conclusion: The incidence rate of neural behavioral abnormality in preschool children with simple obesity is increased, and is related to the severity of obesity, the increase of serum IGF-1 level and decrease of GH level.
|
|
|
|
|
|
[1] 杜彬,陶芳标.单纯性肥胖儿童饮食与静坐少动生活习惯的病例对照研究[J].中国学校卫生,2016,37(4):511~513.
[2] 陈晓霞,余红,蒋丽萍.绍兴地区3~6岁儿童单纯性肥胖的流行病学调查[J].中国儿童保健杂志,2014,22(3):318~320.
[3] 王珊琳,邵启民,蒋茂莹,等.120例学龄前儿童单纯性肥胖的调查及影响因素分析[J].中国现代医生,2016,54(36):10~13.
[4] 胡亚美江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2012.243~247.
[5] Dumont J, Willis J O, Vizel K, et al. Achenbach child behavior checklist[J]. John Wiley & Sons,2013, 94(11):2119~2123.
[6] Zhang C, Yin A, Li H, et al. Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children[J]. Ebiomedicine,2015,2(8):966~984.
[7] 朱珊珊, 黄凤娟,刘云发.单纯性肥胖儿童身心健康发展状况的实证研究[J].沈阳体育学院学报,2014,33(3):101~105.
[8] 杨一海,张爱莲.单纯性肥胖儿童的社会适应能力研究[J].中国继续医学教育,2015,7(25):72~73.
[9] 郭丹丹.学龄期单纯性肥胖儿童的心理发育特征分析[J].母婴世界,2014,4(13):32~34.
[10] 吕瑞利,卢小蕴.儿童单纯性肥胖与血脂、血糖及内分泌激素水平的相关性分析[J].中国妇幼保健,2018,33(2):347~349.
[11] Xu Y, Liu M C, Wang P, et al. Correlation between serum IGF-1 and blood lead level in short stature children and adolescent with growth hormone deficiency[J]. Int Clin Exp Med,2014,7(4):856~864. |
| [1] |
. [J]. 河北医学, 2017, 23(5): 867-869. |
|
|
|
|
2019, Vol. 25 
