联合检测促甲状腺激素与甲状腺球蛋白在诊断甲状腺良恶性结节的临床价值

doi:10.3969/j.issn.1006-6233.2019.02.008

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Abstract Objective: To analyze the clinical value of combined detection of thyroid stimulating hormone (TSH) and thyroglobulin (Tg) in the diagnosis of benign and malignant thyroid nodules. Methods: The clinical data of 196 patients with thyroid nodules (TN) in our hospital were retrospectively analyzed. According to the results of pathological diagnosis, the patients were divided into malignant group (n=57) and benign group (n=139). Serum TSH and Tg levels were compared between the two groups. Logistic regression analysis and receiver operating curve (ROC curve) were used to evaluate the clinical value of TSH, Tg and the combined examination in the diagnosis of benign and malignant thyroid nodules. Results: Serum TSH and Tg levels in malignant group were higher than those in benign group (P<0.05). The ROC curve of serum TSH level showed AUC was 0.739 (P<0.05), and the critical value was 2.45mIU/L, and the diagnostic sensitivity and specificity were 0.754 and 0.770 respectively. The ROC curve of serum Tg level showed AUC was 0.728 (P<0.05), and the critical value was 72.66ng/mL, and the diagnostic sensitivity and specificity were 0.421 and 0.778 respectively. The AUC of TSH combined with Tg was 0.815, and the sensitivity and specificity were 0.749 and 0.821 respectively, and the above indexes were significantly higher than those of single TSH or Tg (P<0.05). Conclusions: The combined detection of TSH and Tg in the diagnosis of benign and malignant thyroid nodules has good accuracy, sensitivity and specificity, and has certain clinical value.

Key words： Thyroid stimulating hormone Thyroglobulin Benign and malignant thyroid nodules

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.02.008 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I2/205

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