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| Clinical Study of Edaravone combined with Vinpocetine Injection in the treatment of Acute Cerebral Hemorrhage and its effect on Neurological Function |
| GAO Shoujun, et al |
| Ya'an People's Hospital, Sichuan Ya'an 625000, China |
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Abstract Objective: To study the clinical efficacy of edaravone combined with vinpocetine injection in the treatment of acute cerebral hemorrhage and its effect on neurological function. Methods: A total of 86 patients who underwent acute cerebral hemorrhage in our hospital from March 2015 to March 2018 were selected,they were randomly divided into observation group (43 cases) and control group (43 cases). All the patients were given routine treatment, the control group was given vinpocetine injection , the observation group was combined with edaravone. NIH Stroke Scale (NIHSS) score, clinical efficacy, neuron-specific enolated alcohol (NSE), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were compared between two groups. Results: After 2 weeks and after 4 weeks of treatment, The NIHSS score in the observation groups was lower than that of the control group [(11.87 ± 1.22)points, (7.12 ± 0.73)points VS(14.98 ± 1.43)points, (10.98 ± 1.26)points] (P<0.05). After treatment, the total effective rate of the observation group was higher than that of the control group [83.72% (36/43) VS 65.11% (28/43)] (P<0.05). The levels of NSE, TNF-α and IL-6 in the observation group were lower than those in the control group [(8.54±0.76) ug/L,(14.87±1.34) ng/L,(32.54±3.17) ng/L VS (19.43±1.53) ug/L,(24.32±2.76 )ng/L,(47.65±4.22) ng/L] (P<0.05). Conclusion: Acute cerebral hemorrhage using edaravone combined with vinpocetine injection, can effectively improve the patient's neurological function, clinical efficacy is good.
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2019, Vol. 25 
