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| Effects of Dexmedetomidine on the Plasma hs-CRP PCT IL-6 TFC levels and Oxygenation of Patients with ARDS Induced by Sepsis |
| ZHENG Chun, et al |
| Neijiang Municipal First Peoplel's Hospital, Sichuan Neijiang 641000, China |
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Abstract Objective: To study the effects of dexmedetomidineon the plasma high sensitive C reactive protein(hs-CRP), procalcitonin(PCT), interleukins(IL-6), thoracic Fluid(TFC) levels and Oxygenation of Patients with ARDS Induced by Sepsis. Methods: A total of 62 ARDS patients with sepsis admitted to intensive care unit from February 2016 to February 2018 were divided into observation group (n =32) and control group (n = 30) by simple random number table method. On the basis of conventional mechanical ventilation, the control group was given midazolam sedative treatment, while the observation group was given dexmedetomidine sedative treatment, they were combined with fentanyl for analgesia. The clinical efficacy and levels of plasma hs-CRP, PCT, IL-6, TFC, oxygenation index and acute physiology and chronic health scoring system II (APACHE II) score before and after treatment and the ICU length of stay, weaning time and fatality ratewere recorded. Results: After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05). The reduction amplitude of the plasma hs-CRP, PCT, IL-6, TFC, APACHE II scores in the observation group were significantly higher than those in the control group (P<0.05), the increase amplitude of the SaO2, PaO2 PaO2/FiO2 were also significantly higher than those of the control group (P<0.05). The ICU length of stay and weaning time of the observation group were significantly shorter than those of the control group, and the mortality was significantly lower than that of the control group (P<0.05). Conclusion: Dexmedetomidine sedation can reduce the levels of hs-CRP, PCT, IL-6 and TFC in plasma of sepsis-induced ARDS patients, alleviate inflammation, improve oxygenation index, shorten ICU hospitalization time and reduce mortality.
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[1] 王红军,于洪涛,贾金广.52例中度急性呼吸窘迫综合征患者临床分析[J].中国现代医学杂志,2014,24(27):63~68.
[2] 唐甜,谭利平.炎症反应在脓毒症ARDS发病机制中的作用[J].重庆医学,2017,46(15):2146~2149.
[3] 王海军,邢学忠,高勇,等.镇静药物与急性呼吸窘迫综合征近期预后的相关性研究[J].中国医刊,2017,52(10):45~49.
[4] 唐朝霞,管向东.急性呼吸窘迫综合征诊断标准[J].中国实用内科杂志,2013,33(11):838~839.
[5] 黄增相,陶骅,徐雯.乌司他丁对严重脓毒症致急性呼吸窘迫综合征患者血浆C反应蛋白、降钙素原及乳酸水平的影响[J].实用医学杂志,2015,31(10):1692~1694.
[6] 常明,卢红艳,相虹.不同机械通气方式联合肺表面活性物质对新生儿急性肺损伤/急性呼吸窘迫综合征疗效比较[J].中国当代儿科杂志,2016,18(11):1069~1074.
[7] 韩惠芳,徐宇红,岳静燕.俯卧位不同翻身时间对急性呼吸窘迫综合征机械通气患者的影响[J].中华护理杂志,2013,48(10):923~925.
[8] 田昭涛,李慧丽,张树柳,等.乌司他丁对ARDS患者氧合指数、血清hs-CRP水平及血管外肺水指数的影响[J].山东医药,2014,54(6):65~66.
[9] 慕月晶,王伟佳,严海忠,等.PCT检测在全身和局部细菌感染诊断中的临床应用[J].检验医学,2015,30(1):17~20.
[10] 陈少媚,曾凡杰,叶伟华,等.右美托咪啶在脓毒症ARDS患者机械通气治疗中的应用[J].山东医药,2016,56(2):58~59. |
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2019, Vol. 25 
