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| Curative Efficacy of Anerning Granules combined with Budesonide in treatment of Bronchopneumonia and Effects on Serum IGF- II GM-CSF and sIL-2R levels |
| HOU Xiaoyan, GAO Guangchuan, FENG Qin |
| Guang'an People's Hospital, Sichuan Guang'an 638000, China |
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Abstract Objective: To study the curative efficacy of anerning granules combined with budesonide in treatment of bronchopneumonia and effects on serum insulin-like growth factor(IGF)- II, granulocyte-macrophage colony-stimulating factor(GM-CSF) and Solubility interleukin-2 receptor(sIL-2R) levels. Methods: 90 patients of bronchopneumonia who received therapy from March 2015 to March 2018 in our hospital were selected as research objects, according to the simple random number table, those patients were divided into the 44 cases of the observation group and the 46 cases of the control group, on the basis of routine treatment, the control group was treated with budesonide suspension, while the observation group was treated with anerning granules on the basis of the control group, they were treated continuously for 7 days. The clinical efficacy, the changes of the laboratory indexes, serum levels of IGF-II, GM-CSF, sIL-2R and adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was 93.18%, which was significantly higher than that of the control group 73.91% (P<0.05); there were significant differences in C-reactive protein (CRP), white blood cell count (WBC), serum levels of IGF-II, GM-CSF and sIL-2R between the observation group and the control group after treatment [(1.79±0.30)mg/L vs (5.11±0.31)mg/L,(5.49±1.14)×109/L vs(7.26±1.52)×109/L,(0.39±0.04)ng/ml vs(0.67±0.08)ng/ml,(0.43±0.05)μg/L vs(0.71±0.09)μg/L, (132.83±11.51)pg/ml vs (159.47±14.74)pg/ml](P<0.05). The fever, cough, shortness of breath and lung rales disappeared times in the observation group were significantly shorter than that of the control group [(2.89±0.30)d vs (4.11±0.47)d, (4.05±0.49)d vs(5.29±0.55)d,(3.48±0.37)d vs(4.82±0.48)d,(3.27±0.40)d vs(4.71±0.45)d](P<0.05). There was no obvious adverse reaction in the two groups during treatment. Conclusion: In children with bronchial pneumonia, the use of Anerning Granule combined with budesonide suspension has a significant effect, which can help to reduce the expression of serum IGF-II, GM-CSF, sIL-2R, and promote the recovery of disease. It is safe and worthy of application and promotion.
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2019, Vol. 25 
