榄香烯注射液辅助顺铂方案在非小细胞肺癌术后患者中的疗效及对错配切割修复蛋白表达的影响

doi:10.3969/j.issn.1006-6233.2019.01.018

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Abstract Objective: To study the effect of elemene injection assisted cisplatin in patients with non-small cell lung cancer and the effect of mismatch-cleaved repair protein (ERCC1) expression. Methods: 73 patients with postoperative lung cancer admitted to our hospital from June 2013 to February 2016 were randomly divided into observation group (n=40 ) and control group (n=33). The control group received chemotherapy with cisplatin. The observation group was intravenously instilled with elemene injection on the basis of the control group. The clinical treatment effect, long-term survival rate, ERCC1 expression and toxic side effects were observed and compared between the two groups. Results: After treatment, the total effective rate was 80% in the observation group and 72.7% in the control group. There was no significant difference between the two groups (P>0.05). The positive rate of ERCC1 in the observation group was 100% (40/40), the high expression rate was 65% (26/40), the positive rate in the control group was 78.8% (26/33), and the high expression rate was 24.2% (8/33), the positive rate and high expression rate of the two groups were significantly different (P<0.05). Gastrointestinal reactions, myelosuppression, allergic reactions and renal dysfunction were observed in both groups, but the incidence of toxic and side effects in the observation group was significantly lower than that in the control group [(55%), (45%). (2.5%), (20%) vs (84.8%), (75.8%), (9.1), (45.5%)], there were significant differences in toxicity and side effects between the two groups (P<0.05). After 2 years of follow-up, the overall survival rate of the observation group was 37.5%, the median survival time was 19.5 months, and the 1-year survival rate was 67.5%. The overall survival rate of the control group was 18.2%, the median survival time was 9.2 months, and the 1-year survival rate was 42.4%. There was significant difference in survival rate between the two groups (P<0.05). Conclusion: Elemene injection can alleviate the toxicity and side effects of patients with non-small cell lung cancer and improve the therapeutic effect. It can also reduce the drug resistance of cancer cells and increase the expression of mismatch cutting repair protein.

Key words： Non-small cell lung cancer Elemene Chemotherapy Toxic side effects Mismatched repair protein

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	ZHANG Li
	ZHANG Jing
	WANG Yuan
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ZHANG Li,ZHANG Jing,WANG Yuan, et al. Efficacy of Elemene Injection Assisted Cisplatin in Patients with Non-small Cell Lung Cancer and Influence on the Expression of Mismatched Repair Proteins[J]. HeBei Med, 2019, 25(1): 70-74.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.01.018 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I1/70

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