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| Effect of Azithromycin combined with Siqikang Injection on Bronchitis Asthma and the Influences on MDSCs IgE and Eotaxin |
| XIA kui, et al |
| Huaibei People's Hospital, Anhui Huaibei 235000, China |
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Abstract Objective: To study the effect of Azithromycin combined with Skikang injection on bronchial asthma and its effects on Myeloid-derived suppressor cells (MDSCs), serum immunoglobulin E IgE and eosinophil activated chemotactic factor Eotaxin. Methods: 102 patients of Bronchitis asthma who received therapy from March 2017 to April 2018 in our hospital were selected as research objects. According to simplerandom number table, those patients were divided into the observation group (n=42) and the control group (n=38). The control group was treated with Skikang injection, while the observation group was treated with azithromycin on the basis of the control group. The curative effect, disappearance time of clinical symptoms, pulmonary function indexes (forced expiratory volume in one second, maximum expiratory volume in the first second, percentage of forced expiratory volume in the first second, MDSCs, IgE and Eotaxin levels) were observed before and after treatment. Results: After treatment, the total effective rate of observation group was statistically higher than that in the control group [95.23%(40/42)vs 73.68%(28/38)] (P<0.05); The time of disappearance of clinical symptoms was significantly lower than that of the control group [(2.98±0.87)d vs (6.90±1.32)d,(2.07±0.60)d vs(5.10±0.90)d,(3.97±1.02)d vs(6.70±1.58)d](P<0.05); FEV1、FEV1/FVC、PEF were higher than those of the control group [(3.02±0.78)L vs(2.47±0.50)L,(88.38±20.47)% vs(79.59±15.38)%, (7.32±1.90)% vs (6.37±1.51)%](P<0.05); The levels of FEV1, FEV1/FVC and PEF were higher than those of the control group [(3.02±0.78)L vs(2.47±0.50)L,(88.38±20.47)% vs(79.59±15.38)%,(7.32±1.90)% vs(6.37±1.51)%](P<0.05); The levels of MDSCs, IgE and Eotaxin were lower than those of the control group [(0.85±0.21)% vs(2.76±0.20)%,(78.19±14.02)% vs (91.45±17.71)%, (0.07±0.02)% vs (0.19±0.04)% ](P<0.05). Conclusion: Azithromycin combined with cichikang injection has a significant effect on bronchitis asthma. It can improve the clinical symptoms, inhibit the release of inflammation and reduce the level of MDSCs, IgE and Eotaxin. It can be used as a reliable method to treat bronchitis.
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2019, Vol. 25 
