|
|
|
| Effect of Dexmedetomidine combined with Lornoxicam on Restlessness and Stress Response after Total Hip Arthroplasty |
| WANG Yeqing |
| Xuancheng People's Hospital, Anhui Xuancheng 242000, China |
|
|
|
|
Abstract Objective: To study Effect of dexmedetomidine combined with lornoxicam on restlessness and stress response after total hip arthroplasty. Methods: 100 patients undergoing total hip arthroplasty who received therapy from June 2017 to May 2018 in our hospital were selected as research objects. According to simple random number table, those patients were divided into the observation group (n=48) and the control group (n=52). The control group was treated with dexmedetomidine, while the observation group was treated with dexmedetomidine combined with lornoxicam. Then the VAS score, Harris hip score, stress response level (Cor, E, NE) and incidence of adverse reactions of two groups before and after treatment were compared. Results: The postoperative 12h, postoperative 24h, postoperative 36h and postoperative 72hVAS scores in the observation group were significantly lower than those in the control group(P<0.05). Postoperative 7d and postoperative 14d harris hip score were significantly higher than those of the control group(P<0.05). Postoperative 12h, postoperative 24h, postoperative 36h, postoperative 72hCor, E and NE levels were significantly lower than those in the control group(P<0.05). Incidence of adverse reactions were significantly lower than those in the control group [12.50%(6/48)vs 30.76%(16/52)](P<0.05). Conclusion: The sedative and analgesic effects of dexmedetomidine combined with lornoxicam in adjuvant patients undergoing total hip artroplasty are remarkable. It can stabilize hemodynamics, reduce stress response, reduce the incidence of post-restlessness, relieve the pain of patients, and is conducive to postoperative recovery.
|
|
|
|
|
|
[1] 杨云丽,魏辉明,张承华,等.氯诺昔康对老年患者全髋置换术后舒芬太尼皮下自控镇痛效果的影响[J].中国临床药理学与治疗学,2014,19(2):190~195.
[2] Bowman EN, McCabe MP, Cleveland KB.Effectiveness of thrombin-collagen and autologous platelet-rich plasma in total hip arthroplasty hemostasis: a prospective, randomized, controlled trial[J].Surg Orthop Adv Summer,2018,(2):136~141.
[3] 韩阳东,陈鹏,赵加,等.盐酸右美托咪定配合舒芬太尼镇痛泵对老年髋关节置换病人术后镇痛及髋关节功能康复的影响[J].中国实验诊断学,2014,18(8):1354~1355.
[4] Duplantier NL, Rivere AE, Cohen AJ, et al. Hip and knee arthroplasty outcomes after abdominal organ transplantation[J].Surg Orthop Adv Summer, 2018,27(2):119~124.
[5] 秦燕,何崎,刘丹凤.右美托咪定对老年患者全髋关节置换术七氟烷麻醉苏醒期躁动的影响[J].深圳中西医结合杂志,2015,25(7):20~22.
[6] Altay M, Demirkale, atma MF, et al. Results of crowe type IV developmental dysplasia of hip treated by subtrochantric osteotomy and total hip arthroplasty[J].Indian Orthop,2018,52(4):374~379.
[7] 杨燕,张运琼.右美托咪定用于老年全髋关节置换术的临床观察及对患者炎症因子的影响[J].实用老年医学,2015,29(9):766~768.
[8] Park KS, Chan CK, Lee DH, et al. Midterm results of conversion from failed bipolar hemiarthroplasty to total Hip arthroplasty[J].Indian Orthop,2018,52(4):369~373.
[9] 陈岩.右美托咪定联合喷他佐辛对老年患者全髋关节置换术后的镇痛效果及炎症因子、Fib和D-二聚体水平的影响[J].东南大学学报(医学版),2017,36(6):934~937.
[10] Bohra M, Cwian D, Peyton C. Delayed infection in a patient after total hip arthroplasty[J].Orthop Sports Phys Ther,2018,48(8):666.
[11] 王诚静,邓朝阳,尹丽.右美托咪定对全麻下老年患者髋关节置换术血流动力学的影响[J].湘南学院学报(医学版),2016,18(1):46~47.
[12] Cunningham D, Karas V, DeOrio J, et al. Patient risk factors do not impact 90-day readmission and emergency department visitation after total ankle arthroplasty: implications for the comprehensive care for joint replacement (CJR) bundled payment Plan[J].Bone Joint Surg Am,2018,100(15):1289~1297.
[13] 张付化.右美托咪定对老年骨折患者七氟烷麻醉苏醒期躁动影响分析[J].医药论坛杂志,2016,37(2):172~173.
[14] 申玲,刘素萍,朱书朝.氯诺昔康对老年髋关节置换术后皮下患者自控镇痛的疗效观察[J].中国医院用药评价与分析,2016,16(12):1656~1659. |
|
|
|
2019, Vol. 25 
