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Montelukast Sodium in the Treatment of Children with Acute Attack of Bronchial Asthma and the effect on the CD4+ CD8+ and CD4+/CD8+ Levels |
CHEN Liang, LIN Yuantao, ZHOU Hongyu |
Zigong First People's Hospital, Sichuan Zigong 643000, China |
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Abstract Objective: To explore the clinical effect of montelukast sodium in children with acute attack of bronchial asthma and its influence on CD4+, CD8+ and CD4+/CD8+ levels. Methods: 76 children with acute attack of bronchial asthma in our hospital from June 2015 to June 2018 were selected and randomly divided into observation group and control group, 38 cases in each group. The control group was treated with routine oxygen inhalation and fluid replacement, while the observation group was treated with montelukast sodium. The levels of CD4+, CD8+, CD4+/CD8+, forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume (FEV1), changes of symptom score and improvement time of symptoms were compared between the two groups before and after treatment. Results:After treatment, the levels of CD4+, CD4+ /CD8+ in the immune function of the observation group were significantly higher than those of the control group [(39.25±7.15)% vs (32.87±6.38)%, (1.89±0.53) vs (1.37±0.54)] (P<0.05), and the level of CD8+ was significantly lower than that of the control group [(25.06±8.04)% vs (30.54±6.26)%] (P<0.05); The FVC, PEF and FEV1 in the observation group were higher than those in the control group [(79.24±7.11)% vs (68.48±5.26)%,(1.40±0.44)L/s vs (1.17±0.34)L/s, (76.55±3.55)% vs (65.85±3.46)%] (P<0.05); The symptom relief, time and signs disappeared in the observation group, all lower than those in the control group [(3.34±0.75)d vs (5.64±1.05)d, (5.22±1.17)d vs (7.62±1.55)d] (P<0.05); The daily symptom score and night symptom score of the observation group were lower than that of the control group [(1.12±0.45) score vs (1.63±0.58) score, (1.16±0.46) score vs (2.03±0.75) score] (P<0.05). Conclusion:On the basis of routine treatment for children with acute attack of bronchial asthma, montelukast sodium treatment can effectively improve the immune function and lung function of children, shorten the treatment time, and have a significant effect.
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