尼莫地平联合拉坦前列腺素治疗原发性开角型青光眼的疗效及对房水EPO ET-1 sCD44的影响

doi:10.3969/j.issn.1006-6233.2019.01.007

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Abstract Objective: To study the curative efficacy of nimodipine combined with latanoprost in treatment of primary open-angle glaucoma and effects on the aqueous humor erythropoietin(EPO), endothelin-1(ET-1), soluble CD44(sCD44) levels. Methods: 91 patients of primary open-angle glaucoma who received therapy from June 2015 to June 2017 in our hospital were selected as research objects, according to the random number table, those patients were divided into the 46 cases of observation group and the 45 cases of control group. The control group was treated with latanoprost, while the observation group was treated with nimodipine on the basis of the control group, they were continuous treatment for 6 months. The clinical efficacy, the changes of visual related index, optic disc sieve plate blood flow, aqueous humor EPO, ET-1, sCD44 levels and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the observation group was 93.48% (43/46), which was significantly higher than that of the control group 77.78% (35/45) (P<0.05). The intraocular pressure and visual field defect in the observation group were significantly lower than that of the control group [(16.57±1.54)mmHg vs(18.72±1.85)mmHg,(9.21±1.10)dB vs(11.37±1.20)dB], the retinal light sensitivity and visual acuity were significantly higher than that of the control group[(18.74±2.30)dB vs(16.89±2.03)dB,(0.76±0.12)vs(0.71±0.09)](P<0.05). In the optic disc sieve plate blood flow, the blood flow velocity, blood flow and erythrocyte mobility in the observation group were significantly higher than that of the control group [(188.42±20.56)mm/s vs(167.34±17.57)mm/s,(15.68±1.62)L/min vs(12.73±1.50)L/min,(1.04±0.15)vs(0.83±0.10)](P<0.05); and the aqueous humor EPO, ET-1, sCD44 levels in the observation group were significantly lower than that of the control group [(7.05±1.17)mU/ml vs (8.49±1.45)mU/ml,(43.72±4.59)ng/L vs(51.04±5.64)ng/L,(13.40±1.39)ng/ml vs(18.15±1.70)ng/ml](P<0.05). During the treatment, the incidence of adverse reactions in the two groups was 10.87% (5/46) and 8.89% (4/45) respectively, and the difference was not statistically significant (P>0.05). Conclusion: The effect of nimodipine combined with latanoprostaglandin in patients with primary open angle glaucoma is remarkable. Its intrinsic mechanism may be related to the reduction of EPO, ET-1 and sCD44 expression in aqueous humor. Moreover, the safety of nimodipine combined with latanoprostaglandin is high, and it is worth popularizing.

Key words： Primary open-angle glaucoma Latanoprost Nimodipine Erythropoietin Endothelin-1 Soluble CD44

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	LIU Shuang
	KONG Fanhong
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LIU Shuang,KONG Fanhong,et al. Curative Efficacy of Nimodipine combined with Latanoprost in Treatment of Primary Open-angle Glaucoma and Effects on the Aqueous Humor EPO ET-1 sCD44 Level[J]. HeBei Med, 2019, 25(1): 25-29.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.01.007 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I1/25

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