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| Application Study of bFGF Combined with Ultrasonic Bone Scalpel in Removal of Impacted Mandibular Teeth |
| WEI Endian, FU Xiao, YOU Jingxiu |
| Chuzhou First People's Hospital, Anhui Chuzhou 239000, China |
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Abstract Objective: To explore the application effectiveness of recombinant bovine basic fibroblast growth factor (bFGF) combined with ultrasonic bone scalpel in the removal of impacted mandibular teeth.Methods: A total of 105 patients with impacted mandibular teeth treated at our hospital from October 2020 to October 2023 were randomly divided into a control group (n=52) and an observation group (n=53) using simple random grouping. The control group underwent bFGF combined with conventional rotary drilling for extraction, while the observation group underwent bFGF combined with ultrasonic bone scalpel for extraction. Surgical-related indicators, clinical treatment outcomes, postoperative swelling, restricted mouth opening recovery, expression levels of inflammatory factors [tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule 1 (ICAM1), myeloperoxidase (MPO)] in gingival crevicular fluid, and dry socket occurrence were compared between the two groups.Results: The operation time and intraoperative blood loss in the observation group were significantly lower than those in the control group (P<0.05). Before and after surgery, the improvement in systolic blood pressure, diastolic blood pressure, and blood glucose levels in the observation group was lower than that in the control group (P<0.05). The excellent and good treatment rate in the observation group was 98.11%, which was higher than 82.69% in the control group (P<0.05). Postoperative swelling and incidence of restricted mouth opening were lower in the observation group compared to the control group (P<0.05). The increase in TNF-α, ICAM1, and MPO levels in the gingival crevicular fluid was lower in the observation group than in the control group (P<0.05). The total incidence of complications in the observation group was lower than that in the control group (P<0.05).Conclusion: bFGF combined with ultrasonic bone scalpel for the treatment of impacted mandibular teeth is effective, improves inflammatory responses in gingival crevicular fluid, and reduces the risk of complications.
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2024, Vol. 30 
