Th1/Th2平衡及HLA-DQA1基因多态性与血液透析导管性感染的相关性

doi:10.3969/j.issn.1006-6233.2024.08.019

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Abstract Objective: To explore the correlation between Th1/Th2 balance, human leukocyte antigen DQA1 (HLA-DQA1) gene polymorphism, and catheter-related infections during hemodialysis.Methods: Forty-eight patients with hemodialysis catheter-related infections treated at our hospital from January 2020 to January 2024 were selected as the observation group. Two hundred sixty patients undergoing hemodialysis without catheter-related infections during the same period were selected as the control group. The differences in Th1 cells, Th2 cells, associated cytokines, and HLA-DQA1 gene polymorphisms between the two groups were compared.Results: The Th1, Th2, TNF-α, TGF-1, IL-4, and IL-6 levels in the observation group were (43.35±9.10)%, (3.10±0.92)%, (46.22±8.87) pg/mL, (50.05±13.36) pg/mL, (1.03±0.35) pg/mL, and (40.05±11.65) pg/mL, respectively, higher than those in the control group (P<0.05), while Th1/Th2 levels were (14.01±2.20), lower than those in the control group (P<0.05). There was a statistically significant difference in HLA-DQA1 genotype between the observation group and the control group (P<0.05). The TNF-α, IL-4, and IL-6 of the observation group's deceased patients were (58.07±2.65) pg/mL, (1.22±0.21) pg/mL, and (46.67±9.96) ng/L, respectively, higher than those of the surviving patients (P<0.05). There was no statistically significant difference in HLA-DQA1 gene polymorphism between surviving and deceased patients in the observation group (P>0.05).Conclusion: Patients with hemodialysis catheter-related infections exhibit elevated levels of Th1 cells, Th2 cells, and associated factors. There are differences in HLA-DQA1 genotypes between patients with and without infections, with TNF-α, IL-4, and IL-6 levels associated with prognosis.

Key words： Th1 Th2 Human leukocyte antigen DQA1 gene polymorphism Hemodialysis catheterization infection

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	HE Fan
	YANG Wenjun
	MA Li
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Cite this article:

HE Fan,YANG Wenjun,MA Li, et al. Correlation of Th1/Th2 Balance and HLA-DQA1 Gene Polymorphism with Hemodialysis Catheter-Related Infections[J]. HeBei Med, 2024, 30(8): 1336-1340.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.08.019 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I8/1336

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