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| Analysis of Lipid Profile and Homocysteine Levels in Subclinical Hypothyroidism Patients and Their Relationship with TSH |
| MA Wangwen, ZHAO Yanping, LI Wenya |
| Suzhou Kowloon Hospital, School of Medical, Shanghai Jiaotong University, Jiangsu Suzhou 215028, China |
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Abstract Objective: To analyze the levels of blood lipids and homocysteine (Hcy) in patients with subclinical hypothyroidism (SCH) and their relationship with thyroid-stimulating hormone (TSH). Methods: A total of 119 patients diagnosed with SCH between March 2020 and March 2023 were selected as the SCH group. Additionally, 121 healthy individuals with normal health examination indicators during the same period were selected as the normal control group. Blood lipid metabolism, Hcy, and TSH levels were compared between the SCH group and the normal control group. Within the SCH group, subgroup analysis (SCH1 and SCH2) based on TSH levels was conducted to compare lipid metabolism and Hcy levels. Correlation analysis using partial correlation coefficients and multiple linear regression were performed to assess the association between blood lipid metabolism, Hcy levels, and TSH levels. Results: Compared with the normal control group, the SCH group showed higher levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), Hcy, and TSH (P<0.05). There were no statistically significant differences in high-density lipoprotein cholesterol (HDL-C), free triiodothyronine (FT3), and free thyroxine (FT4) levels between the SCH group and the normal control group (P>0.05). Subgroup analysis within the SCH group revealed that TC, LDL-C, and Hcy levels were higher in SCH2 compared to SCH1 (P<0.05). There were no significant differences in TG, HDL-C, FT3, and FT4 levels between SCH1 and SCH2 (P>0.05). After adjusting for gender, age, BMI, smoking history, fasting plasma glucose (FPG), and TSH, multiple linear regression analysis indicated that TSH was a risk factor for abnormalities in TC, TG, LDL-C, and Hcy levels, while the linear regression relationship between TSH and HDL-C was not statistically significant(P>0.05). Conclusion: Patients with subclinical hypothyroidism exhibit alterations in blood lipid metabolism and Hcy levels, which are influenced by TSH levels. Therefore, monitoring blood lipid metabolism and Hcy levels in patients with subclinical hypothyroidism should be strengthened. This study provides a new perspective for clinicians to assess and manage cardiovascular risks in patients with subclinical hypothyroidism.
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[1] 谢杨,石波,刘家开,等.亚临床甲状腺功能减退症患者血清TSH水平与心外膜脂肪厚度的关系[J].郑州大学学报(医学版),2022,57(6):858-861.
[2] 唐萍,王其美.妊娠期亚临床甲减孕妇不同孕期TSH水平变化及对低出生体重儿的预测价值研究[J].中国妇产科临床杂志,2021,22(3):246-248.
[3] 张蕊,秦诗阳,何建秋,等.老年2型糖尿病大血管病变患者亚临床甲状腺功能减退与血脂及血清hs-CRP、CysC的相关性[J].中国老年学杂志,2021,41(19):4190-4193.
[4] 朱美荣,徐进.2型糖尿病与甲状腺功能异常共患发生的危险因素分析[J].山东医药,2021,61(34):63-66.
[5] 苗曦,王晓宇,马利双,等.合肥市某区人群亚临床甲状腺功能减退症中促甲状腺激素水平与代谢综合征发病的相关性[J].安徽医科大学学报,2022,57(8):1318-1322.
[6] Treister-Goltzman Y,Yarza S,Peleg R.Lipid profile in mild subclinical hypothyroidism:systematic review and meta-analysis[J].Minerva Endocrinol (Torino),2021,46(4):428-440.
[7] 单忠艳.《中国甲状腺疾病诊治指南》导读[J].中国实用内科杂志,2008,28(4):260-261.
[8] 白梦坡,穆耶赛尔·麦麦提明,刘惠娟,等.原发性高血压患者亚临床甲状腺功能减退与中心动脉压相关指标及脉搏波速度之间的关系[J].临床心血管病杂志,2022,38(4):318-322.
[9] Chen Y,Tai HY.Levothyroxine in the treatment of overt or subclinical hypothyroidism:a systematic review and meta-analysis[J].Endocr,2020,67(7):719-732.
[10] Jarvis JN,Lawrence DS,Meya DB,et al.Single-dose liposomal amphotericin B treatment for cryptococcal meningitis[J].N Engl Med,2022,386(12):1109-1120.
[11] Gong N,Gao C,Chen X,et al.Endothelial function in patients with subclinical hypothyroidism:a meta-analysis[J].Horm Metab Res,2019,51(11):691-702.
[12] Liu J,Chen Y,Ren B,et al.Alteration of lipid profile between subclinical hypothyroidism and well-matched controls:a meta-analysis[J].Horm Metab Res,2023,55(7):479-486. |
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2024, Vol. 30 
