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The Relationship Between EEG Abnormalities and Serum BDNF GFAP miR-7-5p Expression Characteristics and Cognitive Function in Epilepsy Patients |
BAI Yang, YANG Yue, QI Huizhen |
The Fifth Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China |
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Abstract Objective: To explore the relationship between EEG abnormalities, serum levels of Brain-Derived Neurotrophic Factor (BDNF), Glial Fibrillary Acidic Protein (GFAP), and miR-7-5p expression characteristics, and cognitive function in epilepsy patients. Methods: The study included 294 epilepsy patients treated at our hospital from April 2017 to April 2021. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. Patients were divided into two groups based on their MoCA scores: 198 patients with scores ≥26 were included in the cognitively normal group, while 96 patients with scores <26 were included in the cognitive impairment group. All patients underwent EEG examinations. The study compared EEG abnormalities and serum levels of BDNF, GFAP, and miR-7-5p between the groups and investigated their association with cognitive impairment. Results: Analysis of the MoCA scores showed that patients in the cognitive impairment group had significantly lower scores than those in the cognitively normal group (P<0.05). Compared to the cognitively normal group, patients in the cognitive impairment group had a lower proportion of normal EEGs and higher rates of epileptiform discharges and slow-wave activity (P<0.05). Serum levels of BDNF and miR-7-5p were lower, while GFAP levels were higher in the cognitive impairment group (P<0.05). Pearson correlation analysis indicated that cognitive function in epilepsy patients was positively correlated with BDNF and miR-7-5p levels and negatively correlated with GFAP levels (P<0.05). ROC curve analysis demonstrated that BDNF, miR-7-5p, and GFAP levels have diagnostic value for cognitive impairment in epilepsy patients, with AUC values of 0.836, 0.845, and 0.957, respectively. Conclusion: The abnormal characteristics of EEG in patients with cognitive impairment are mainly EEG discharge and slow wave distribution of EEG. The expression of serum BDNF and miR-7-5p is lower than that of patients with normal epilepsy, and the expression of GFAP is higher than that of patients with normal epilepsy, and serum BDNF, miR-7-5p and GFAP have certain diagnostic value for the occurrence of cognitive impairment in patients with epilepsy.
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[1] Beghi E.The Epidemiology of epilepsy[J].Neuroepidemiology,2020,54(2):185-191. [2] Katyayan A,Diaz-Medina G.Epilepsy:epileptic syndromes and treatment[J].Neurol Clin,2021,39(3):779-795. [3] Benbadis SR,Beniczky S,Bertram E,et al.The role of EEG in patients with suspected epilepsy[J].Epileptic Disord,2020,22(2):143-155. [4] 王满利,章晓富,樊玉香,等.癫痫患者血清长链非编码RNA母系表达基因3、miR-7-5p表达与认知功能的关系[J].中国卫生检验杂志,2022,32(24):2998-3002. [5] Zhao J,Wang B.MiR-7-5p enhances cerebral ischemia-reperfusion injury by degrading sirt1 mRNA[J].Cardiovasc Pharmacol,2020,76(2):227-236. [6] Pinto TCC,Machado L,Bulgacov TM,et al.Is the montreal cognitive assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) in the elderly?[J] Int Psychogeriatr,2019,31(4):491-504. [7] Pinto LF,Adda CC,Silva LC,et al.Contralateral interictal and ictal EEG epileptiform activity accentuate memory impairment in unilateral mesial temporal sclerosis patients[J].Neuropsychology,2017,31(3):268-276. [8] Babiloni C,Del Percio C,Lizio R,et al.Cortical sources of resting state electroencephalographic alpha rhythms deteriorate across time in subjects with amnesic mild cognitive impairment[J].Neurobiol Aging,2014,35(1):130-142. [9] 李陶乐,许虹.运用事件相关电位评价颞叶癫痫患者认知功能及其与头颅磁共振和脑电图异常的相关性分析[J].中华医学杂志,2019,99(27):2115-2118. [10] 姚晓娟,陈旨娟,毓青,等.脑电图-功能磁共振成像技术对局灶性癫痫致痫灶定位的价值[J].中华医学杂志,2015,95(13):987-990. [11] 朱慧,肖正军,高茂军.癫痫患者事件相关电位P300及影响因素研究[J].中国实用神经疾病杂志,2016(3):14-15. [12] 闻红斌.血清BDNF、IGF-1及Hcy与癫痫患者认知功能损害关系研究[J].基因组学与应用生物学,2018,37(10):4547-4552. [13] Xu H,Nie B,Liu L,et al.Curcumin prevents brain damage and cognitive dysfunction during ischemic-reperfusion through the regulation of miR-7-5p[J].Curr Neurovasc Res,2019,16(5):441-454. [14] Li X,Li G,Jin Y,et al.Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p[J].Toxicol Mech Methods,2022,32(6):453-462. |
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. [J]. HeBei Med, 2023, 29(8): 1402-1405. |
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