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| Relationship between Levels of IgA, D-Dimer, and Fibrinogen Degradation Products and Disease Recurrence in Children with Henoch-Schonlein Purpura |
| YANG Yang, TANG Shuai, ZHANG Jian |
| Henan University of Chinese Medicine, Henan Zhengzhou 450046, China |
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Abstract Objective: To explore the relationship between immunoglobulin A (IgA), D-dimer (D-D), fibrinogen degradation products (FDP) levels, and disease recurrence in children with Henoch-Schonlein Purpura (HSP).Methods: A total of 160 children with HSP admitted to our hospital from November 2022 to April 2023 were selected as the study subjects. IgA levels were measured using a fully automatic biochemical analyzer, and D-D and FDP levels were determined using a fully automatic blood coagulation analyzer. After a 6-month follow-up, the patients were divided into the recurrence group (n=34) and the non-recurrence group (n=136) based on the follow-up results. The levels of IgA, D-D, and FDP were compared between the two groups. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to analyze the predictive value of each indicator for disease recurrence. Multifactorial logistic regression analysis was employed to assess the impact of various indicators on disease recurrence. Results: Children in the recurrence group had higher levels of IgA [3.305 (2.565, 4.402)g/L], D-D [1.470 (0.477, 2.742)μg/mL], and FDP [4.445 (2.442, 9.212)μg/mL] compared to the non-recurrence group with IgA [2.360 (1.697, 3.012)g/L], D-D [0.310 (0.200, 0.575)μg/mL], and FDP [1.920 (1.140, 2.890)μg/mL], and the differences were statistically significant (P<0.05). ROC curve analysis revealed that the AUC for the combined prediction of IgA, D-D, and FDP for disease recurrence in HSP children was 0.892, higher than individual indicators, with a sensitivity of 85.3% and specificity of 82.5%. Multifactorial logistic analysis showed that IgA>3.235 g/L, D-D>0.415 μg/mL, and FDP>3.260μg/mL were independent factors for HSP recurrence (P<0.05). Conclusion: IgA, D-D, and FDP levels have a certain predictive value for disease recurrence in HSP. Monitoring the levels of these three indicators is beneficial for evaluating the prognosis.
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[1] Leung A,Barankin B,Leong K.Henoch-schnlein purpura in children:an updated review[J].2020,16(4):265-276.
[2] Lei W T,Tsai P L,Chu S H,et al.Incidence and risk factors for recurrent Henoch-Schnlein purpura in children from a 16-year nationwide database[J].Pediatric Rheumatology,2018,16(1):25.
[3] Li M,Guo B,Wang X,et al.Risk factors of renal trauma in children with severe henoch-schonlein purpura and effect of mycophenolate mofetil on pediatric renal function[J].Translational pediatrics,2021,10(12):3166-3174.
[4] 史洋洋,毕凌云,杨达胜.儿童紫癜性肾炎和IgA肾病的发病机制及病理分型研究进展[J].新乡医学院学报,2021,38(4):386-389.
[5] 胡君伟,吕荣芬.儿童过敏性紫癜凝血纤溶系统变化与肾损伤的相关性[J].血栓与止血学,2021,27(5):837-838.
[6] 张林,朱国琴,葛婷婷,等.过敏性紫癜患儿外周血25-(OH)D3、CD4+/CD8+、免疫球蛋白水平与疾病复发的关系研究[J].中国妇幼健康研究,2023,34(9):7-12.
[7] 孙元元,孙欣,李艳,等.过敏性紫癜患者心理状况调查[J].中国卫生产业,2017,14(27):152-153.
[8] 朱凯莉,黄燕萍.儿童过敏性紫癜复发危险因素的研究进展[J].中国妇幼健康研究,2021,32(12):1882-1885.
[9] 周金洁.IgA血管炎的病因和发病机制研究进展[J].皮肤科学通报,2022,39(6):547-551.
[10] 王颖,姚玉淑.小儿过敏性紫癜急性期外周血CD4+、CD8+T细胞及免疫球蛋白的变化及意义[J].吉林医学,2022,43(4):929-930.
[11] 张艳,宋晓彤,王云,等.过敏性紫癜患儿复发的影响因素及IgE、IgA水平对其预测价值[J].分子诊断与治疗杂志,2021,13(12):2034-2037.
[12] 曾艳芬,曹鹏驹,窦敏.纤维蛋白(原)降解产物/D-二聚体比值的临床应用探讨[J].福建医药杂志,2023,45(4):16-19.
[13] 熊丽君,陈巧彬,郑少娟,等.过敏性紫癜儿童凝血纤溶系统异常与早期肾损伤的相关性[J].现代临床医学,2022,48(5):324-326,331.
[14] 高鸿博,王艳飞,隗晓华,等.D-D、FIB、IL-18、IGF-1与儿童过敏性紫癜患者预后的相关分析[J].河北医药,2023,45(6):829-832.
[15] 伍文彪.D-二聚体和纤维蛋白降解产物(FDP)在过敏性紫癜的临床应用及研究进展[J].临床医药文献电子杂志,2020,7(40):194-196.
[16] 李逸群,杜桂贤,张彩霞.过敏性紫癜患者纤维蛋白原、D-二聚体水平与紫癜性肾炎患者尿微量白蛋白的相关性研究[J].卫生职业教育,2021,39(10):107-109. |
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2024, Vol. 30 
