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| Correlation Study and Risk Factor Analysis of Non-Erosive Gastroesophageal Reflux Disease with Mucosal Bulge Lesions at the Esophagogastric Junction |
| LONG Xiaotian, ZHANG Meng, et al |
| Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To explore the correlation between non-erosive gastroesophageal reflux disease (NERD) and the mucosal bulge lesions of esophagogastric junction, and to provide the basis for the diagnosis of NERD under endoscopy. Risk factors of NERD were also analyzed. Methods: A prospective study was conducted on patients who underwent gastroscopy from January 2022 to December 2022. Patients meeting the inclusion criteria were categorized into the NERD group, while asymptomatic patients who underwent gastroscopy during the same period were included in the control group. General demographic and endoscopic factors were compared between the two groups, and the relationship between NERD and mucosal bulge lesions at the esophagogastric junction was analyzed. Results: Univariate analysis revealed significant differences in gender, age, BMI, dietary habits, drinking, NSAID use, gastroesophageal flap valve classification, mucosal bulge lesions at the esophagogastric junction, bile reflux, and HP infection between the NERD and control groups (P<0.05). Logistic regression analysis identified female gender, high BMI, poor dietary habits, drinking, NSAID use, gastroesophageal flap valve relaxation (III+IV), mucosal bulge lesions at the esophagogastric junction, bile reflux, and HP infection as factors influencing NERD. The sensitivity and specificity of mucosal bulge lesions at the esophagogastric junction for NERD were 45.83% and 86.27%, respectively. Conclusion: Mucosal bulge lesions at the esophagogastric junction are significantly correlated with NERD, serving as supportive diagnostic evidence and enhancing diagnostic reliability. Female gender, high BMI, drinking, NSAID use, poor dietary habits, gastroesophageal flap valve relaxation (Ⅲ+Ⅳ), and bile reflux are independent risk factors for NERD, while HP infection is a protective factor.
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2024, Vol. 30 
