血NT-proBNP CRP和NLR水平在评估慢性阻塞性肺疾病急性加重合并肺部感染患者预后的价值

doi:10.3969/j.issn.1006-6233.2024.02.010

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Abstract Objective: To investigate the prognostic value of blood N-terminal prohormone of brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with AECOPD and pulmonary infection. Methods: From December 2019 to December 2021, 120 patients with AECOPD and pulmonary infection were admitted to the hospital. Their clinical data were analyzed retrospectively. Patients enrolled were divided into survival group (n=86) and death group (n=34) according to the prognosis. General data, blood NT-proBNP, CRP and NLR were compared. The prognostic value of the three in patients with AECOPD and pulmonary infection was analyzed using the receiver operating characteristic (ROC) curve. Results: Compared with the death group, blood NT-proBNP, CRP and NLR in the survival group were lower (P<0.05). ROC curve analysis results showed that the area under the curve (AUC) of NLR for predicting the prognosis of patients with AECOPD and pulmonary infection was the largest, with sensitivity of 73.53% and specificity of 63.95%. The AUC of CRP was the smallest, with sensitivity of 47.06% and specificity of 82.56% (P>0.05). The AUC of parallel prediction with the combination of blood NT-proBNP, CRP and NLR was 0.700. The sensitivity and specificity were 97.06% and 43.02%. Conclusion: Blood NT-proBNP, CRP and NLR are of high value in the prognosis of patients with AECOPD and pulmonary infection. In clinical practice, NT-proBNP, CRP and NLR can be used as auxiliary indicators to predict the patient's condition, thus improving the prognosis.

Key words： Chronic obstructive pulmonary disease Pulmonary infection N-terminal prohormone of brain natriuretic peptide C-reactive protein Neutrophil to lymphocyte ratio

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.02.010 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I2/230

[1] Neumeier A,Keith R.Clinical Guideline Highlights for the Hospitalist:The GOLD and NICE Guidelines for the Management of COPD[J].Hosp Med,2020,15(4):240-241.
[2] Januzzi JL Jr,Zannad F,Anker SD,et al.Prognostic importance of NT-proBNP and effect of empagliflozin in the EMPEROR-reduced trial[J].Am Coll Cardiol,2021,78(13):1321-1332.
[3] 吴佳妮,成群,高光霞,等.胸腺肽联合血必净治疗对AECOPD合并脓毒症患者外周血PCT、CRP、IL-6及淋巴细胞表达的影响[J].贵州医科大学学报,2022,47(4):472-476.
[4] 吴滨,杨磊,徐静.NLR、RDW和PLR在老年COPD患者的预测价值研究[J].中国血液流变学杂志,2022,32(3):372-375.
[5] 中华医学会呼吸病分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):255-264.
[6] 中华医学会呼吸病学分会.社区获得性肺炎诊断和治疗指南[J].中国实用乡村医生杂志2013,20(2):11-15.
[7] 彭玉凤,柴芳,邢孔浪,等.阿托伐他汀治疗慢性阻塞性肺疾病患者的临床研究[J].中国临床药理学杂志,2023,39(2):155-159.
[8] 安铁峰,王文科.PSI评分和CURB-65评分判断慢性阻塞性肺疾病急性加重合并肺部感染患者预后的价值[J].内科急危重症杂志,2018,24(5):423-424,430.
[9] 崔翔.血浆磷脂、白三烯B4联合B型脑钠肽诊断慢性阻塞性肺疾病急性加重期患者的临床价值研究[J].标记免疫分析与临床,2019,26(1):56-59.
[10] 步睿,胡昊,李赫.血清NT-proBNP水平与慢性阻塞性肺疾病急性发作患者发生左心室射血功能障碍的相关性分析[J].哈尔滨医科大学学报,2022,56(5):453-457.
[11] 张静,周沈之,李燕,等.血清sCD163、CRP联合纤维蛋白原检测对AECOPD预后的预测价值[J].中国急救复苏与灾害医学杂志,2022,17(10):1327-1330,1335.
[12] 郭桂林,韩军侠,杨发武.血清CRP、NLR及WBC对AECOPD患者细菌感染的早期诊断价值[J].分子诊断与治疗杂志,2022,14(5):760-763,768.
[13] Che-Morales JL,Cortes-Tells A.Neutrophil-to-lymphocyte ratio as a serum biomarker associated with community acquired pneumonia[J].Rev Med Inst Mex Seguro Soe,2019,56(6):537-543.