维持性腹膜透析患者外周血NLR PLR HGB水平变化及其与钙磷代谢异常和全因病死率的关系

doi:10.3969/j.issn.1006-6233.2024.01.018

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Abstract Objective: To explore the changes in peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hemoglobin (HGB) levels in maintenance peritoneal dialysis (PD) patients and their relationship with calcium-phosphorus metabolism abnormalities and all-cause mortality. Methods: A total of 206 maintenance PD patients admitted from March 2019 to June 2022 were selected. Patients were assessed for the presence of calcium-phosphorus metabolism abnormalities and divided into abnormal and normal groups. Peripheral blood NLR, PLR, and HGB levels were compared between the two groups. The correlation between NLR, PLR, HGB, and blood calcium and phosphorus levels was analyzed. Follow-up was conducted until December 2022, with all-cause mortality as the endpoint event. Patients were divided into the death group and the survival group, and peripheral blood NLR, PLR, and HGB levels were compared. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of NLR, PLR, and HGB for all-cause mortality. Results: In the abnormal group, peripheral blood NLR, PLR, and blood phosphorus levels were higher, while blood calcium levels were lower than those in the normal group (P<0.05). However, there were no statistically significant differences in age, gender, education level, primary disease, dialysis time, and peripheral blood HGB levels between the two groups (P>0.05). In elderly patients undergoing maintenance hemodialysis, peripheral blood NLR and PLR were negatively correlated with blood calcium levels and positively correlated with blood phosphorus levels (P<0.05). However, HGB showed no significant correlation with blood calcium and phosphorus levels (P>0.05). The dialysis time in the death group was longer than that in the survival group. Peripheral blood NLR, PLR, and blood phosphorus levels were higher, while blood calcium levels were lower in the death group compared to the survival group (P<0.05). However, there were no statistically significant differences in age, gender, education level, primary disease, and peripheral blood HGB levels between the two groups (P>0.05). ROC curve analysis showed that the areas under the curve (AUC) for peripheral blood NLR and PLR in predicting all-cause mortality were 0.777 (95% CI: 0.6880.895), respectively. Conclusion: Calcium-phosphorus metabolism abnormalities in maintenance peritoneal dialysis patients are related to peripheral blood NLR and PLR levels. These indicators have a certain predictive value for all-cause mortality in patients.

Key words： Maintenance peritoneal dialysis Neutrophil to lymphocyte ratio Platelet to lymphocyte ratio Hemoglobin Calcium-phosphorus metabolism All cause mortality

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	MEI Jiben
	HE Jing
	CHEN Zhonghui
	et al

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MEI Jiben,HE Jing,CHEN Zhonghui, et al. Changes in Peripheral Blood NLR PLR and HGB Levels in Maintenance Peritoneal Dialysis Patients and Their Relationship with Calcium-Phosphorus Metabolism Abnormalities and All-Cause Mortality[J]. HeBei Med, 2024, 30(1): 93-98.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.018 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/93

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