连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β<sub>2</sub>-MG水平的影响

doi:10.3969/j.issn.1006-6233.2024.01.013

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Abstract Objective: To explore the effects of continuous blood purification (CBP) and intermittent hemodialysis (IHD) on levels of serum retinol-binding protein 4 (RBP4), transferrin (Tf) and β₂-microglobulin (β₂-MG) in elderly patients with acute renal failure (ARF). Methods: A total of 114 ARF patients admitted to our hospital from January 2021 to January 2023 were included in this study. The patients were randomly divided into two groups using a random number table, with 57 cases in each group (observation group and control group). The control group received IHD, and the observation group received CBP, with a dialysis period of 2 weeks for both groups. Clinical efficacy, serum levels [RBP4, Tf, β₂-MG, Serum Creatinine (Scr), and Blood Urea Nitrogen (BUN)] before and 2 weeks after dialysis, as well as electrolyte indicators (K⁺, Cl^-, Na⁺), were compared between the two groups. Complications during the treatment were recorded. Results: After dialysis, the total effective rates in the observation group and control group were 94.74% (54/57) and 78.95% (45/57), respectively, with a statistically significant difference (P<0.05). After 2 weeks of dialysis, the serum levels of RBP4, Tf, β₂-MG, Scr, and BUN in both groups decreased significantly compared to before dialysis, and the reduction in the observation group was greater than that in the control group (P<0.05). After 2 weeks of dialysis, the serum levels of K⁺, Cl^-, and Na⁺ in both groups increased significantly compared to before dialysis, and the increase in the observation group was greater than that in the control group (P<0.05). The incidence of complications during dialysis in both groups (5.26%, 7.02%) showed no significant difference (P>0.05). Conclusion: CBP is more effective in elderly ARF patients, effectively removing small and large molecular toxins from the blood and maintaining electrolyte stability.

Key words： Acute renal failure Continuous blood purification Intermittent hemodialysis Retinol-binding protein 4 Transferrin β₂-microglobulin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.013 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/71

[1] 徐丽斌,朱立革,刘国平,等.内蒙古老年急性肾损伤的流行病学单中心回顾性研究[J].中国中西医结合肾病杂志,2020,21(10):871-874.
[2] 王克坤,蒙绪君,韩辉,等.血液透析与连续性血液净化透析治疗急性肾衰竭的疗效及对患者毒素清除率和肾功能指标的影响[J].河北医学,2020,26(5):788-792.
[3] Zuccari S,Damiani E,Domizi R,et al.Changes in cytokines,haemodynamics and microcirculation in patients with sepsis/septic shock undergoing continuous renal replacement therapy and blood purification with cytoSorb[J].Blood Purif,2020,49(1-2):107-113.
[4] Koza Y.Acute kidney injury:current concepts and new insights[J].Inj Violence Res,2016,8(1):58-62.
[5] 马丽,曾丽梅,李秀君.中老年人慢性肾功能衰竭病因调查及预后分析[J].公共卫生与预防医学,2022,33(3):142-145.
[6] 赵云峰,徐志华,顾维立.连续性血液净化治疗脓毒症合并急性肾损伤患者效果及对免疫和炎症因子影响[J].中国急救复苏与灾害医学杂志,2021,16(8):895-898.
[7] 丁洁,李峻,伍军,等.连续性与间歇性血液透析治疗肾功能衰竭的效果和安全性对比观察[J].解放军预防医学杂志,2019,37(8):51-52.
[8] 田浩,汪坚,张晓珺,等.不同分期慢性肾脏病患者血清Klotho蛋白、FGF-23、RBP4、TWEAK水平与肾功能的相关性研究[J].现代生物医学进展,2021,21(18):3477-3481.
[9] 邓艳斌,邹振武,段先召.性有机磷中毒患者肾损伤与血清Cys-C、NGAL、β₂-MG的关联研究[J].新疆医科大学学报,2022,45(3):244-249.
[10] 赵春莉,曹昌萌,柳颖,等.间歇与连续血液透析治疗急性肾衰竭的效果及对患者毒素清除率和肾功能指标的影响[J].中国临床保健杂志,2021,24(5):671-674.
[11] 张卫东,刘莲琴.连续性血液净化和间歇性血液透析对老年急性肾衰竭患者电解质水平的影响比较[J].检验医学与临床,2020,17(4):552-555.