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| Effects of Oxycodone and Remifentanil Combined with Propofol on Hemodynamics, Neurological Function and Prognosis of Patients Operated for Craniocerebral Injury |
| QIAO Yan, LIAO Xingzhi, CHEN Tian, et al |
| 904 Hospital of Joint Logistics Support Force, Jiangsu Wuxi 214044, China |
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Abstract Objective: To explore the effects of oxycodone and remifentanil combined with propofol on hemodynamics, neurological function and prognosis of patients with craniocerebral injury. Methods: A total of 150 patients with craniocerebral injury admitted from September 2019 to September 2021 were selected as the study subjects and randomly divided into study group and control group, with 75 patients in each group. The study group was given oxycodone combined with propofol, and the control group was given remifentanil combined with propofol. The levels of hemodynamics [Oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR)] before operation (T0), 30 minutes after anesthesia (T1), immediately after operation (T2), and 24 hours after operation (T3) were compared between the two groups, and the levels of nerve function [Tau protein (Tau), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP)] at T0 and T3 were compared. The prognosis of the two groups was compared after 3 months follow-up. Results: The differences of SpO2, MAP and HR between the two groups and at different time points and the interaction between time and groups were statistically significant (P<0.05). At T0, there were no differences in serum Tau, NSE and GFAP levels between two groups (P>0.05). At T3, the levels of serum Tau, NSE and GFAP in both groups were lower than those at T0, and the reduction degree in the study group was greater than that in the control group (P<0.05). There were no deaths in the two groups, and the prognosis of the study group was better than that of the control group (P<0.05). Conclusion: Compared with remifentanil combined with propofol, oxycodone combined with propofol can obtain a more stable hemodynamic level in patients with craniocerebral injury, and can significantly improve the neurological function and prognosis of patients, which is more worthy of clinical application.
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2023, Vol. 29 
