Angptl2 YKL-40和SII水平与高血压合并不稳定型心绞痛患者相关性研究

doi:10.3969/j.issn.1006-6233.2023.07.08

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Abstract Objective: To investigate the diagnosis value of combined angiotensin-like protein 2 (Angptl2),chitinase protein 40 (YKL-40) and systemic immune inflammatory index (SII) levels for essential hypertension (EH) combined with unstable angina (UA) and to analyze their correlation with the degree of coronary artery lesions. Methods: The clinical data of 161 patients admitted with EH to the Affiliated Hospital of Chengde Medical University from December 2020 to December 2021 were collected.They were divided into EH group (n=76) and EH+UA group (n=85) according to whether they had UA.The serum Angptl2 and YKL-40 levels were measured separately in the two groups,and the SII levels were calculated according to the corresponding formula.General information and differences in Angptl2,YKL-40 and SII levels were compared between the groups.Multi-factor logistic regression was used to analyse independent influences on EH+UA,Spearman's rank correlation was used to analyse the correlation between Angptl2,YKL-40 and SII levels and the degree of coronary artery disease,and ROC curves were used to analyse the sensitivity and specificity of Angptl2,YKL-40 and SII levels in predicting EH+UA. Results: The levels of low-density lipoprotein cholesterol (LDL-C),supersensitive C-reactive protein (hsCRP),white blood cells (WBC),neutrophil count (Neutrophil),SII,Angptl2 and YKL-40 were higher in the EH+UA group than in the EH group (all P<0.05); the lymphocyte count (Lymphocyte) was lower in the EH+UA group than in the EH group (P<0.05).Angptl2,YKL-40 and SII levels may be independent predictors of EH+UA (P<0.05) and positively correlated with Angptl2,YKL-40 and SII levels and Gensini score (P<0.05).SII,Angptl2 and YKL-40 in the diagnosis of EH+UA.The area under the ROC curve (AUC) was 0.783 (95% CI:0.714-0.853 ),0.789 (95% CI:0.721-0.858 ) and 0.86 (95% CI:0.806-0.914),respectively,and the AUC of the three combined diagnoses was greater than that of SII,Angptl2 and YKL-40 alone or both AUC,and was more sensitive. Conclusion: Abnormal up-regulation of Angptl2,YKL-40 and SII levels may be a risk predictor for EH+UA,and high levels of Angptl2,YKL-40 and SII may also be a predictor for assessing the severity of coronary artery lesions,and the combined test is more valuable for the diagnosis of EH+UA.

Key words： Essential hypertension Unstable angina Chitinase protein 40 Angiotensin-like protein 2 Systemic immunoinflammatory index Gensini score

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.07.08 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I7/1099

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