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| Efficacy and Safety of Ultrasound-Guided Subcutaneous Methylene Blue Injection Combined with Acupotomy in the Treatment of Postherpetic Neuralgia |
| WANG Le, WANG Zeai, LU Qin, et al |
| Huai'an Hospital, Xuzhou Medical University / Huai'an Second People's Hospital, Jiangsu Huai'an 223002, China |
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Abstract Objective: To explore the clinical efficacy and safety of ultrasound-guided subcutaneous methylene blue injection combined with acupotomy in the treatment of postherpetic neuralgia (PHN). Methods: The clinical data of patients with PHN who were treated with ultrasound-guided subcutaneous methylene blue injection in the hospital from March 2020 to May 2022 were retrospectively analyzed, and 40 cases were randomly selected as control group. The clinical data of patients with PHN who received ultrasound-guided subcutaneous methylene blue injection combined with acupotomy in the hospital during the same period were retrospectively analyzed, and 50 cases were randomly enrolled as study group. The clinical efficacy of the two groups of patients after 10 days of treatment was counted. The pain status [Zoster Brief Pain Inventory (ZBPI), Houston Pain Outcome Instrument (HPOI)], sleep quality [Athens Insomnia Scale (AIS), Pittsburgh Sleep Quality Index (PSQI)] and quality of life [Quality of Life Index Questionnaire (QL-index), Brief Pain Inventory (BPI)] were compared between the two groups of patients before treatment and after 10 days of treatment, and the occurrence of adverse reactions during treatment in the two groups were recorded. Results: At weeks after the end of treatment, the total effective rate of clinical treatment in study group (88.0%) was significantly higher than that in control group (70.0%) (P<0.05). After 10 days of treatment, the scores of ZBPI, PSQI, AIS and BPI in the two groups were significantly lower than those before treatment, and the scores in study group were significantly lower compared with those in control group (P<0.05). The HPOI score and QL-index score in the two groups after 10 days of treatment were significantly higher than those before treatment, and the scores were significantly higher in study group than those in control group (P<0.05). During treatment, there was no statistically significant difference in the total incidence rate of adverse reactions between study group (14.0%) and control group (7.5%) (P>0.05). Conclusion: Ultrasound-guided subcutaneous methylene blue injection combined with acupotomy can effectively enhance the clinical therapeutic effectiveness and reduce the pain degree of patients with PHN, and it has a good improvement effect on sleep and quality of life and has good safety.
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2023, Vol. 29 
