肺癌骨转移患者SPECT/CT最大标准化摄取值及血清ALP N-MID TPINP水平及意义分析

doi:10.3969/j.issn.1006-6233.2023.05.022

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Abstract Objective: To investigate the significance of the maximum standardized uptake value (SUVmax) of single photon emission computed tomography(SPECT)/computed tomography(CT), serum alkaline phosphatase (ALP), N-terminal intermediate molecular fragment of osteocalcin (N-MID), and total type I procollagen N-terminal prepreptide (TPINP) in patients with bone metastasis from lung cancer. Methods: A total of 107 lung cancer patients treated in our hospital from January 2021 to June 2022 were selected, including 37 patients with bone metastasis and 70 patients without bone metastasis, the differences of SUVmax, ALP, N-MID and TPINP between patients with bone metastasis and patients without bone metastasis were compared, and the relationship between SUVmax, ALP, N-MID and TPINP and clinicopathological characteristics was analyzed, as well as the value of ALP, N-MID and TPINP in diagnosing bone metastasis. Results: The ALP, N-MID and TPINP of patients with bone metastasis were (120.30 ± 33.32) U/L, (19.03 ± 3.54) μg/L and (82.21 ± 26.65) μg/L, respectively, which were significantly higher than those of patients without bone metastasis (P<0.05), while the lumbar bone mineral density (BMD) was (0.82 ± 0.12), (0.74 ± 0.11) and (0.66 ± 0.14), respectively, which was significantly lower than that of patients without bone metastasis (P<0.05). SUVmax in patients with adenocarcinoma was (11.45 ± 1.98), which was significantly lower than that in patients with squamous cell carcinoma and other types (P<0.05). The SUVmax of tumor diameter>5cm and TNM stage Ⅲ~Ⅳ were (13.38 ± 1.95) and (12.99 ± 2.00) respectively, which were significantly higher than those of patients with treatment diameter ≤ 5cm and TNM stage Ⅰ~Ⅱ (P<0.05). ALP, N-MID and TPINP in TNM stage Ⅲ~Ⅳ were (110.39 ± 21.12) U/L, (18.62 ± 2.22) μg/L and (70.31 ± 17.02) μg/L respectively, which were significantly higher than those in TNM stage Ⅰ~Ⅱ patients (P<0.05). The area under ROC curve of ALP, N-MID and TPINP in diagnosing bone metastasis was 0.695, 0.734 and 0.837 respectively (P<0.05). Conclusion: Compared with lung cancer patients with without bone metastasis, the levels of ALP, N-MID and TPINP in lung cancer patients with bone metastasis are significantly higher, while SUVmax has no significant difference; SUVmax, ALP, N-MID and TPINP have a certain relationship with the clinicopathological characteristics of lung cancer patients. Among them, ALP, N-MID and TPINP have a certain application value in the diagnosis of bone metastasis of lung cancer.

Key words： Lung cancer Bone metastasis Single photon generation computed tomography Maximum standardized uptake value Alkaline phosphatase N-terminal fragment of osteocalcin Total type I procollagen N-terminal propeptide

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.05.022 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I5/808

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