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| Analysis of Clinical Characteristics and Factors Associated with the Occurrence of Sarcopenia in Elderly Patients after Esophageal Squamous Carcinoma Surgery |
| WANG De’en, YANG Wei, WANG Weimin, et al |
| Huai'an First Hospital,Nanjing Medical University, Jiangsu Huai'an 223300, China |
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Abstract Objective: To analyze the clinical characteristics and related factors of sarcopenia (SA) in elderly patients after esophageal squamous carcinoma surgery. Methods: A retrospective analysis was performed on the clinical data of 120 elderly patients with esophageal squamous carcinoma admitted to the hospital between March 2018 and October 2021. According to L3 skeletal muscle index (L3 SMI) and international diagnostic criteria for SA (male: L3 SMI ≤40.8cm2/m2, female: L3 SMI ≤34.9cm2/m2), the patients were divided into SA group (n=49) and non-SA group (n=71). Postoperative clinical characteristics of the two groups were recorded, and the influencing factors of SA were screened by logistic regression analysis. Results: There were statistically significant differences in general data [age, Karnofsky Performance Scale (KPS) score, body mass index (BMI), and serum prealbumin (PA)] between the two groups (P<0.05), but there was no statistically significant difference in the other clinical indexes (P>0.05). Logistic regression analysis showed that age, KPS score and BMI were influencing factors of SA. Conclusion: The occurrence of SA in elderly patients after esophageal squamous carcinoma surgery is related to multiple factors. Clinically, attention should be paid to the related factors of SA, timely and targeted intervention measures should be taken to reduce the incidence of postoperative SA.
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[1] 左娇娇.食管癌术后患者无痛胃镜检查存在误吸高风险的影响因素[D].四川:电子科技大学,2022.
[2] Kim JW,Kim R,Choi H,et al.Understanding of sarcopenia:from definition to therapeutic strategies[J].Arch Pharm Res,2021,44(9-10):876-889.
[3] 江涛,王新航,张露艺,等.中国老年人肌少症患病率的Meta分析[J].海南医学,2022,33(1):116-123.
[4] 王欢,张磊,谭志强,等.老年肌少症的综合干预研究进展[J].成都医学院学报,2020,15(3):405-408.
[5] 中国抗癌协会肿瘤营养专业委员会.肿瘤相关性肌肉减少症临床诊断与治疗指南[J].肿瘤代谢与营养电子杂志,2022,9(1):24-34.
[6] Friendlander AH,Ettinger RL.Karnofsky performance status scale[J].Spec Care Dentist,2009,29(4):147-148.
[7] 刁勇,李智慧,李小凯,等.胸段食管鳞癌术后复发模式及术后放疗靶区的研究[J].现代肿瘤医学,2022,30(13):2420-2424.
[8] 刘海霞,周萍,张一娜.肌少症的诊断与治疗[J].中华骨质疏松和骨矿盐疾病杂志,2021,14(4):434-440.
[9] 张玲玲.恶性肿瘤患者人体成分和肌肉减少症的现况研究[D].河北:河北医科大学,2019.
[10] 李周华,季爽,胡先纬,等.肺癌患者并发肌肉减少症的危险因素分析及其与临床预后的相关性探讨[J].中国全科医学,2021,24(26):3310-3315,3322.
[11] 周锡垒,于长华,朱卫国,等.肌少症对食管鳞癌术后复发患者放化疗不良反应及预后影响[J].中华放射肿瘤学杂志,2022,31(9):785-790. |
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2023, Vol. 29 
