高通量透析联合血液灌流对维持性血液透析患者营养状况及钙磷代谢的影响

doi:10.3969/j.issn.1006-6233.2023.04.07

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Abstract Objective: To investigate the effect of high flux dialysis (HFD) combined with hemoperfusion (HP) on nutritional status and calcium-phosphorus metabolism in maintenance hemodialysis (MHD) patients. Methods: A total of 87 patients who underwent MHD in the 363 Hospital from January 2019 to January 2022 were selected, and randomly divided into 2 groups. Patients in the observation group (n=44) were treated with HFD combined with HP, and patients in the control group (n=43) were treated with conventional hemodialysis. Both groups received 3 consecutive months of treatment. The two groups were compared on nutritional status, inflammatory status, calcium-phosphorus metabolism level, and sleep quality before and after treatment, and adverse reactions were recorded. Results: After treatment, the levels of serum albumin (ALB), prealbumin (PA), hemoglobin (HB) and body mass index (BMI) were increased, while the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF-α), blood calcium, blood phosphorus and intact parathyroid hormone (iPTH), calcium-phosphorus product and Pittsburgh Sleep Quality Index (PSQI) were significantly reduced. The changes of serum ALB, PA, HB, IL-6, hs-CRP, TNF-α, blood calcium, blood phosphorus, iPTH, calcium-phosphorus product and PSQI scores in the observation group before and after treatment were greater than those in the control group (P<0.05). The incidence rates of skin pruritus, myalgia and fatigue in the observation group (9.09%, 11.36% and 9.09%) were lower than those in the control group (30.23%, 32.56% and 25.58%) (P<0.05). Conclusion: HFD combined with HP can effectively improve the nutritional status of MHD patients, correct micro-inflammatory state and calcium-phosphorus metabolism, improve sleep quality, and reduce adverse reactions.

Key words： High flux dialysis Hemoperfusion Maintenance hemodialysis Nutritional status Calcium-phosphorus metabolism

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	TANG Yueqiu
	LU Xiaomei

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TANG Yueqiu,LU Xiaomei. Effect of High Flux Dialysis Combined with Hemoperfusion on Nutritional Status and Calcium-Phosphorus Metabolism in Maintenance Hemodialysis Patients[J]. HeBei Med, 2023, 29(4): 561-566.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.04.07 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I4/561

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