利妥昔单抗对视神经脊髓炎患者视力及肠道菌群的影响分析

doi:10.3969/j.issn.1006-6233.2023.03.031

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Abstract Objective: To investigate the effect of rituximab on vision and intestinal flora in patients with neuromyelitis optica. Methods: A total of 127 patients with neuromyelitis optica admitted to our hospital from March 2018 to March 2021 were selected for research, and they were divided into a study group (n=64) and a control group (n=63) by a simple random method using a random number table. Both groups were given hormone pulse therapy in the acute phase, the study group was given rituximab therapy in the remission phase, and the control group was given cyclophosphamide intravenous infusion therapy in the remission phase. The Disability Status Scale (EDSS) was used to evaluate the treatment effect. The visual acuity and intestinal flora distribution before and after 8 weeks of treatment were compared between the two groups, and the incidence of adverse reactions during the treatment was compared. The study was followed up for 1 year to compare the recurrence of the two groups. Results: After treatment, the function of EDSS subitems in the two groups recovered significantly compared with that before treatment (P<0.05). The differences of cone system function, brain stem function, vesicorectal function and visual function scores in the study group before and after treatment were higher than those in the control group (P<0.05). The worst eye, the best eye and the average logMAR corrected visual acuity after treatment in the two groups. The difference before and after treatment in the study group was higher than that in the control group (P<0.05), and the recurrence rate was lower than that in the control group (P<0.05). After treatment, the Chaol index and Shannon index were (233.15±15.26) and (3.36±0.68), respectively, which were higher than those of the control group (P<0.05), and there was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Rituximab has obvious effects on improving vision and intestinal flora structure in patients with neuromyelitis optica, and has the value of popularization and application.

Key words： Rituximab Neuromyelitis optica Visual acuity Gut flora Safety

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.03.031 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I3/507

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