新活素注射液联合速尿治疗难治性心力衰竭疗效及对心功能血气指标和血清NT-pro BNP PCT水平的影响

doi:10.3969/j.issn.1006-6233.2023.03.010

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Abstract Objective: To investigate the effect of recombinant human brain natriuretic peptide for injection combined with furosemide in the treatment of refractory heart failure, and the influence on cardiac function, blood gas indexes, serum N-terminal pro-brain natriuretic peptide (NT-pro BNP) and procalcitonin (PCT) levels. Methods: The clinical data of 108 cases of refractory heart failure treated in our hospital from January 2018 to December 2021 were retrospectively collected. They were divided into a control group (n=54, furosemide) and an observation group (n=54, furosemide combined with Recombinant Human Brain Natriuretic Peptide for Injection) by different medication methods. Clinical effects, cardiac function, blood gas indexes, serum NT-pro BNP and PCT levels were compared between the two groups. Results: The treatment response rate in the observation group (94.44%) was higher than that in the control group (81.48%) (P<0.05). The values of stroke volume left ventricular ejection fraction, left ventricular end-systolic diameter, and left ventricular end-diastolic diameter in the observation group before and after treatment were higher than those in the control group(P<0.05). The differences in arterial partial pressure of oxygen (PaO₂), arterial partial pressure of carbon dioxide (PaCO₂), and pH values in the observation group before and after treatment were higher than those in the control group (P<0.05). The differences in serum NT-pro BNP and PCT levels in the observation group before and after treatment were higher than those in the control group(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Recombinant human brain natriuretic peptide for injection combined with furosemide is effective in the treatment of refractory heart failure, which can effectively improve the patient's cardiac function and blood gas indexes, and regulate serum NT-pro BNP and PCT levels.

Key words： Heart failure Recombinant human brain natriuretic peptide for injection Furosemide Cardiac function Serum N-terminal pro-brain natriuretic peptide Procalcitonin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.03.010 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I3/402

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